A comparison of loop electrosurgical excision procedures between human immunodeficiency virus-seropositive and-seronegative women

Helen E. Cejtin, Radha Malapati, Sushma Chaparala

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Objective: The purpose of this study was to compare preoperative and postoperative factors between human immunodeficiency virus (HIV)-seropositive and-seronegative women having a loop electrosurgical excision procedure (LEEP). Our hypothesis is that cervical intraepithelial neoplasia (CIN) presents differently in immunocompromised women. MATERIALS AND Methods: A database of LEEPs performed from October 2004 to November 2009 at John H. Stroger Jr. Hospital, Cook County, Illinois, was created. Patients were considered to have persistent/recurrent disease if they had a cytological diagnosis of atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion, or worse with no histology or a histological diagnosis of CIN 1 or worse at any time after their LEEP. χ Analysis was performed to evaluate differences between HIV-seropositive and-seronegative women. Results: There were 886 LEEPs performed during the study period, 92 among HIV-seropositive and 794 among HIV-seronegative women. Overall, 64.7% had any cytology or histology performed after their procedure, and seropositive women were more likely to follow up (p =.004). Preoperative cytological and cervical histological diagnoses were not different between seropositive and negative women; however, a preoperative endocervical curettage, which was positive, was more common among seropositive women (p <.0001). Human immunodeficiency virus-seropositive women were more likely to have CIN on LEEP histology (p =.04), and more likely to have positive margins (p <.0001) and recurrent/persistent disease (p <.0001). Conclusions: The spectrum of cervical disease was very different between HIV-seropositive and-negative women having LEEPs in our study. Practitioners managing HIV-infected women should be aware of these differences and counsel and follow up appropriately.

Original languageEnglish (US)
Pages (from-to)37-41
Number of pages5
JournalJournal of Lower Genital Tract Disease
Volume15
Issue number1
DOIs
StatePublished - Jan 1 2011

Keywords

  • HIV
  • Loop electrosurgical excision procedure
  • cervical intraepithelial neoplasia

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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