A comparison of measurement properties between EORTC QLU-C10D and FACT-8D in patients with hematological malignances

Yiyin Cao, Haofei Li, Ling Jie Cheng, Madeleine T. King, Georg Kemmler, David Cella, Hongjuan Yu*, Weidong Huang*, Nan Luo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To perform a comparison of the measurement properties of two cancer-specific Multi-Attribute Utility Instruments (MAUIs), EORTC QLU-C10D and FACT-8D, in Chinese patients with hematologic malignancies (HM). Methods: We conducted a longitudinal study on patients with HM in China, using QLU-C10D and FACT-8D at baseline and follow-up (3–4 months from baseline). We assessed: (i) convergent validity using Spearman’s rank correlation test (r) with EQ-5D-5L; (ii) clinical-groups validity by differentiating cancer stages, overall health assessment (OHA), Eastern Cancer Oncology Group (ECOG) performance status, and mental health status. We also examined clinical validity with effect size (ES) and relative efficiency (RE); (iii) responsiveness to changes in patient self-perception using receiver operating characteristics (ROC) curves and area under the curves (AUC); and (iv) agreement using intraclass correlation coefficients (ICC) and visualized with Bland-Altman plot. Results: Among the 308 patients with HM at baseline, 131 completed the follow-up survey. Agreement between the two measures was high (ICC = 0.76). Both measures were highly correlated with EQ-5D-5 L and significantly differentiated (p < 0.001) among groups categorized by cancer stage, OHA performance status, and mental health. ESs for QLU-C10D were numerically higher for cancer stage, OHA, and performance status (ES = 0.53–1.49), whereas ES was higher for FACT-8D and mental health status (ES = 1.35). Responsiveness was higher for QLU-C10D (AUC = 0.84) compared to FACT-8D (AUC = 0.78). Conclusion: Both QLU-C10D and FACT-8D are valid cancer-specific MAUIs for evaluating patients with HM. However, scholars should consider their slight differences in focus when choosing between the two measures.

Original languageEnglish (US)
Article number79
JournalHealth Economics Review
Volume14
Issue number1
DOIs
StatePublished - Dec 2024

Funding

This work was supported by the National Natural Science Foundation of China (Grant No. 72274045, 71974048).

Keywords

  • Cancer
  • FACT-8D
  • Hematological malignance
  • Measurement properties
  • QLU-C10D

ASJC Scopus subject areas

  • Health Policy

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