A comparison of survival and disease-specific survival in surgically resected, lymph node-positive bronchioloalveolar carcinoma versus nonsmall cell lung cancer: Implications for adjuvant therapy

John M. Varlotto, John C. Flickinger, Abram Recht, Margaret C. Nikolov, Malcolm M. DeCamp

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

BACKGROUND. The objective of this study was to assess whether disease-specific survival (DSS) and overall survival (OS) differed among patients who had N1 and N2 bronchioloalveolar carcinoma (BAC) compared with patients who had non-BAC nonsmall cell lung cancer (NSCLC). METHODS. The Surveillance, Epidemiology, and End Results (SEER) Program database from 1992 to 2002 contained 684 patients with BAC and 9809 patients with non-BAC NSCLC who had N1/N2 tumors and who underwent a definitive surgical procedure. OS and DSS rates were compared according to potential prognostic factors, including the use of a matched-pair analysis. RESULTS. The BAC patients with either pathologic N1 or N2 lymph node status were significantly more likely to be women, and nonblack/nonwhite race, but significantly less likely to have poorly differentiated or undifferentiated tumors than patients with non-BAC cancers with comparable lymph node status. The median follow-up of all patients was 29 months. There was a significant difference in DSS between patients with N2 BAC and non-BAC cancers, but not for patients with N1 disease. There was a nonsignificant trend toward longer OS for patients with N2 BAC compared with non-BAC cancers. CONCLUSIONS. Patients with lymph node-positive BAC had distinctly different patient and tumor characteristics than patients with lymph node-positive non-BAC NSCLC. Because DSS appears to be better for patients with N2 BAC, they may not benefit as much from adjuvant therapy as patients with non-BAC NSCLC.

Original languageEnglish (US)
Pages (from-to)1547-1554
Number of pages8
JournalCancer
Volume112
Issue number7
DOIs
StatePublished - Apr 1 2008

Keywords

  • Bronchioloalveolar carcinoma
  • Disease-free survival
  • Lymph node-positive
  • Nonsmall cell carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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