Abstract
Two forms of vitamin E, tocopherol and tocotrienol, were tested for chemopreventive activity in two chemically induced rat mammary-tumor models. When mammary tumors were induced by 7,12-dimethylbenz(a)anthracene (DMBA, 50 mg/kg), only the tocotrienol group had a statistically significant increase in tumor latency. There was no effect of either compound on tumor multiplicity. When tumors were induced by N-nitrosomethylurea (NMU, 30 mg/kg), neither analogue of vitamin E modified latency, whereas tocotrienol increased tumor multiplicity. In summary, neither vitamin analog had a major impact on mammary-tumor development after tumor induction with either DMBA or NMU.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1068S-1070S |
| Journal | American Journal of Clinical Nutrition |
| Volume | 53 |
| Issue number | SUPPL. 4 |
| State | Published - Apr 1991 |
Keywords
- Cancer
- Chemoprevention
- Mammary carcinogenesis
- Tocopherol
- Tocotrienol
- Vitamin E
ASJC Scopus subject areas
- Nutrition and Dietetics
- Medicine (miscellaneous)
