A comparison of tocopherol and tocotrienol for the chemoprevention of chemically induced rat mammary tumors

M. N. Gould*, J. D. Haag, W. S. Kennan, M. A. Tanner, C. E. Elson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

74 Scopus citations

Abstract

Two forms of vitamin E, tocopherol and tocotrienol, were tested for chemopreventive activity in two chemically induced rat mammary-tumor models. When mammary tumors were induced by 7,12-dimethylbenz(a)anthracene (DMBA, 50 mg/kg), only the tocotrienol group had a stastically significant increase in tumor latency. There was no effect of either compound on tumor multiplicity. When tumors were induced by N-nitrosomethylurea (NMU, 30 mg/kg), neither analogue of vitamin E modified latency, whereas tocotrienol increased tumor multiplicity. In summary, neither vitamin analog had a major impact on mammary-tumor development after tumor induction with either DMBA or NMU.

Original languageEnglish (US)
JournalAmerican Journal of Clinical Nutrition
Volume53
Issue number4 SUPPL.
DOIs
StatePublished - Jan 1 1991

Keywords

  • Cancer
  • Chemoprevention
  • Mammary carcinogenesis
  • Tocopherol
  • Tocotrienol
  • Vitamin E

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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