A Contemporary Analysis of Fournier Gangrene Using the National Surgical Quality Improvement Program

Stanley Y. Kim, James M. Dupree, Brian V. Le, Dae Y. Kim, Lee C. Zhao, Shilajit D Kundu*

*Corresponding author for this work

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective To determine a nationwide contemporary description of surgical Fournier gangrene (FG) and necrotizing fasciitis of the genitalia (NFG) outcomes because historically reported mortality rates for FG and NFG are based on small single-institution studies from the 1980s and the 1990s. Methods The National Surgical Quality Improvement Program is a risk-adjusted surgical database used by nearly 400 hospitals nationwide, which tracks preoperative, intraoperative, and 30-day postoperative clinical variables. Data are extracted from patient charts by an independent surgical clinical reviewer at each hospital. Using the National Surgical Quality Improvement Program data from 2005 to 2009, we calculated 30-day mortality rates and identified preoperative factors associated with increased mortality. Results A total of 650 patients were identified with surgery for FG or NFG. Fourteen patients with do not resuscitate orders placed preoperatively were excluded from analyses. For the remaining 636 patients, the overall 30-day mortality was 10.1% (64 of 636). Fifty-seven percent of patients (360 of 636) were men, 70% (446 of 636) were white, and 13% (81 of 636) were African American. Multivariate logistic regression indicated that increased age (odds ratio [OR], 1.041; P =.004), body mass index (OR, 1.045; P <.001), and preoperative white blood cell count (OR, 1.061; P =.001), and decreased platelet count (OR, 0.993; P <.001) were all associated with increased risk of death. Conclusion We determined a surgical mortality rate for FG-NFG of 10.1%. This rate is about half of historically published estimates and similar to recent studies. The lower rate may indicate improvements in therapy. Increased age, body mass index, and white blood cell count, and decreased platelet count were all associated with an increased risk of 30-day mortality.

Original languageEnglish (US)
Article number18991
Pages (from-to)1052-1057
Number of pages6
JournalUrology
Volume85
Issue number5
DOIs
StatePublished - May 1 2015

Fingerprint

Fournier Gangrene
Quality Improvement
Necrotizing Fasciitis
Genitalia
Mortality
Odds Ratio
Platelet Count
Leukocyte Count
Body Mass Index
Resuscitation Orders
African Americans
Logistic Models
Databases

ASJC Scopus subject areas

  • Urology

Cite this

Kim, Stanley Y. ; Dupree, James M. ; Le, Brian V. ; Kim, Dae Y. ; Zhao, Lee C. ; Kundu, Shilajit D. / A Contemporary Analysis of Fournier Gangrene Using the National Surgical Quality Improvement Program. In: Urology. 2015 ; Vol. 85, No. 5. pp. 1052-1057.
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abstract = "Objective To determine a nationwide contemporary description of surgical Fournier gangrene (FG) and necrotizing fasciitis of the genitalia (NFG) outcomes because historically reported mortality rates for FG and NFG are based on small single-institution studies from the 1980s and the 1990s. Methods The National Surgical Quality Improvement Program is a risk-adjusted surgical database used by nearly 400 hospitals nationwide, which tracks preoperative, intraoperative, and 30-day postoperative clinical variables. Data are extracted from patient charts by an independent surgical clinical reviewer at each hospital. Using the National Surgical Quality Improvement Program data from 2005 to 2009, we calculated 30-day mortality rates and identified preoperative factors associated with increased mortality. Results A total of 650 patients were identified with surgery for FG or NFG. Fourteen patients with do not resuscitate orders placed preoperatively were excluded from analyses. For the remaining 636 patients, the overall 30-day mortality was 10.1{\%} (64 of 636). Fifty-seven percent of patients (360 of 636) were men, 70{\%} (446 of 636) were white, and 13{\%} (81 of 636) were African American. Multivariate logistic regression indicated that increased age (odds ratio [OR], 1.041; P =.004), body mass index (OR, 1.045; P <.001), and preoperative white blood cell count (OR, 1.061; P =.001), and decreased platelet count (OR, 0.993; P <.001) were all associated with increased risk of death. Conclusion We determined a surgical mortality rate for FG-NFG of 10.1{\%}. This rate is about half of historically published estimates and similar to recent studies. The lower rate may indicate improvements in therapy. Increased age, body mass index, and white blood cell count, and decreased platelet count were all associated with an increased risk of 30-day mortality.",
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A Contemporary Analysis of Fournier Gangrene Using the National Surgical Quality Improvement Program. / Kim, Stanley Y.; Dupree, James M.; Le, Brian V.; Kim, Dae Y.; Zhao, Lee C.; Kundu, Shilajit D.

In: Urology, Vol. 85, No. 5, 18991, 01.05.2015, p. 1052-1057.

Research output: Contribution to journalArticle

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AB - Objective To determine a nationwide contemporary description of surgical Fournier gangrene (FG) and necrotizing fasciitis of the genitalia (NFG) outcomes because historically reported mortality rates for FG and NFG are based on small single-institution studies from the 1980s and the 1990s. Methods The National Surgical Quality Improvement Program is a risk-adjusted surgical database used by nearly 400 hospitals nationwide, which tracks preoperative, intraoperative, and 30-day postoperative clinical variables. Data are extracted from patient charts by an independent surgical clinical reviewer at each hospital. Using the National Surgical Quality Improvement Program data from 2005 to 2009, we calculated 30-day mortality rates and identified preoperative factors associated with increased mortality. Results A total of 650 patients were identified with surgery for FG or NFG. Fourteen patients with do not resuscitate orders placed preoperatively were excluded from analyses. For the remaining 636 patients, the overall 30-day mortality was 10.1% (64 of 636). Fifty-seven percent of patients (360 of 636) were men, 70% (446 of 636) were white, and 13% (81 of 636) were African American. Multivariate logistic regression indicated that increased age (odds ratio [OR], 1.041; P =.004), body mass index (OR, 1.045; P <.001), and preoperative white blood cell count (OR, 1.061; P =.001), and decreased platelet count (OR, 0.993; P <.001) were all associated with increased risk of death. Conclusion We determined a surgical mortality rate for FG-NFG of 10.1%. This rate is about half of historically published estimates and similar to recent studies. The lower rate may indicate improvements in therapy. Increased age, body mass index, and white blood cell count, and decreased platelet count were all associated with an increased risk of 30-day mortality.

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