A continuing challenge: N-heterocyclic carbene-catalyzed syntheses of γ-butyrolactones

Kathleen J.R. Murauski, Ashley A. Jaworski, Karl A. Scheidt*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

217 Scopus citations


Catalytic, stereoselective N-heterocyclic carbene-catalyzed reactions facilitate efficient construction of many different heterocyclic compounds, such as the enantioenriched 5-membered (γ) lactones highlighted in this tutorial review. Herein, various strategies to enable formal [3+2] type annulations between electrophilic carbonyl equivalents and homoenolate nucleophiles for the synthesis of γ-lactones are summarized.

Original languageEnglish (US)
Pages (from-to)1773-1782
Number of pages10
JournalChemical Society Reviews
Issue number5
StatePublished - Mar 7 2018

ASJC Scopus subject areas

  • Chemistry(all)


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