A Convenient Synthesis of 3-Alkyl-4-aminobutanoic Acids

Ryszard Andruszkiewicz, Richard B. Silverman

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


A series of 3-alkyl-4-aminobutanoic acids were prepared via the Michael addition of nitromethane to 2-alkenoic esters, followed by catalytic hydrogenation of the resultant 3-(nitromethyl)alkanoic esters using 10% palladium on carbon in acetic acid, and acid hydrolysis of the reduction products.

Original languageEnglish (US)
Pages (from-to)953-955
Number of pages3
JournalSynthesis (Germany)
Issue number12
StatePublished - 1989

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry


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