A Convenient Synthesis of 3-Alkyl-4-aminobutanoic Acids

Ryszard Andruszkiewicz; Richard B. Silverman

doi:10.1055/s-1989-27443

A Convenient Synthesis of 3-Alkyl-4-aminobutanoic Acids

Ryszard Andruszkiewicz, Richard B. Silverman

Chemistry

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

A series of 3-alkyl-4-aminobutanoic acids were prepared via the Michael addition of nitromethane to 2-alkenoic esters, followed by catalytic hydrogenation of the resultant 3-(nitromethyl)alkanoic esters using 10% palladium on carbon in acetic acid, and acid hydrolysis of the reduction products.

Original language	English (US)
Pages (from-to)	953-955
Number of pages	3
Journal	Synthesis (Germany)
Volume	1989
Issue number	12
DOIs	https://doi.org/10.1055/s-1989-27443
State	Published - 1989

ASJC Scopus subject areas

Catalysis
Organic Chemistry

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title = "A Convenient Synthesis of 3-Alkyl-4-aminobutanoic Acids",

abstract = "A series of 3-alkyl-4-aminobutanoic acids were prepared via the Michael addition of nitromethane to 2-alkenoic esters, followed by catalytic hydrogenation of the resultant 3-(nitromethyl)alkanoic esters using 10% palladium on carbon in acetic acid, and acid hydrolysis of the reduction products.",

author = "Ryszard Andruszkiewicz and Silverman, {Richard B.}",

year = "1989",

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language = "English (US)",

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N2 - A series of 3-alkyl-4-aminobutanoic acids were prepared via the Michael addition of nitromethane to 2-alkenoic esters, followed by catalytic hydrogenation of the resultant 3-(nitromethyl)alkanoic esters using 10% palladium on carbon in acetic acid, and acid hydrolysis of the reduction products.

AB - A series of 3-alkyl-4-aminobutanoic acids were prepared via the Michael addition of nitromethane to 2-alkenoic esters, followed by catalytic hydrogenation of the resultant 3-(nitromethyl)alkanoic esters using 10% palladium on carbon in acetic acid, and acid hydrolysis of the reduction products.

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JO - Synthesis

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