A cooperative beads-on-a-string approach to exceptionally stable DNA triplexes

Yan Zheng, Hai Long, George C. Schatz, Frederick D. Lewis*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


A poly(dT) oligomer can serve as the string on which synthetic hairpins possessing poly(dA) and poly(dT) arms connected by a hydrophobic perylene diimide linker are assembled like beads on a string. The synthetic hairpins form head-to-head dimers and trimers, respectively, in the absence of the poly(dT) string and in the presence of a string with inverted polarity at mid-strand. However, they assemble in cooperative head-to-tail fashion on normal poly(dT) oligomers.

Original languageEnglish (US)
Pages (from-to)3830-3832
Number of pages3
JournalChemical Communications
Issue number36
StatePublished - Jan 1 2006

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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