@article{b2b576a4abb047b88861cd22e0c17999,
title = "A cortical-brainstem circuit predicts and governs compulsive alcohol drinking",
abstract = "What individual differences in neural activity predict the future escalation of alcohol drinking from casual to compulsive? The neurobiological mechanisms that gate the transition from moderate to compulsive drinking remain poorly understood. We longitudinally tracked the development of compulsive drinking across a binge-drinking experience in male mice. Binge drinking unmasked individual differences, revealing latent traits in alcohol consumption and compulsive drinking despite equal prior exposure to alcohol. Distinct neural activity signatures of cortical neurons projecting to the brainstem before binge drinking predicted the ultimate emergence of compulsivity. Mimicry of activity patterns that predicted drinking phenotypes was sufficient to bidirectionally modulate drinking. Our results provide a mechanistic explanation for individual variance in vulnerability to compulsive alcohol drinking.",
author = "Siciliano, {Cody A.} and Habiba Noamany and Chang, {Chia Jung} and Brown, {Alex R.} and Xinhong Chen and Daniel Leible and Lee, {Jennifer J.} and Joyce Wang and Vernon, {Amanda N.} and {Vander Weele}, {Caitlin M.} and Kimchi, {Eyal Y.} and Myriam Heiman and Tye, {Kay M.}",
note = "Funding Information: We thank Y.-N. Leow for experimental assistance and C. Wildes and R. Wichmann for technical assistance. Funding: C.A.S. was supported by NIH grants F32 MH111216 (NIMH) and K99 DA045103 (NIDA) and a NARSAD Young Investigator Award from the Brain and Behavior Research Foundation. K.M.T. is a New York Stem Cell Foundation–Robertson Investigator and McKnight Scholar and was supported by funding from the JPB Foundation, New York Stem Cell Foundation, R01-MH102441 (NIMH), the NIH Director{\textquoteright}s New Innovator Award DP2-DK102256 (NIDDK), and Pioneer Award DP1-AT009925 (NCCIH). M.H. was supported by the JPB Foundation. D.L. is enrolled as a student at the Medical Faculty Heidelberg, Heidelberg University, Germany, and was supported by a fellowship from the Boehringer Ingelheim Fonds. Publisher Copyright: {\textcopyright} 2019 American Association for the Advancement of Science. All rights reserved.",
year = "2019",
month = nov,
day = "22",
doi = "10.1126/science.aay1186",
language = "English (US)",
volume = "366",
pages = "1008--1012",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6468",
}