A cycle involving HMGB1, IFN-γ and dendritic cells plays a putative role in anti-tumor immunity

Qun Gao, Feng Li, Shumin Wang, Z. Shen, Shaoyan Cheng, Yu Ping, Guohui Qin, Xinfeng Chen, Li Yang, Ling Cao, Shasha Liu, Bin Zhang, Liping Wang, Yan Sun, Yi Zhang*

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

An important subset in regulating antitumor immunity is the maturation and accumulation of intratumor dendritic cells (DCs), inducing potent T cell cytotoxicity. In this study, we explored how the soluble abundant high-mobility group box 1 protein (HMGB1) affected DC activation and retention within lung cancers, and in which way the resultant interferon-γ (IFN-γ) further enhanced DC maturation and accumulation. It was discovered that HMGB1 was correlated with DC markers HLA-DR and CD86 in lung cancers at both mRNA and protein level. Further analyses showed HMGB1 enhanced the maturation of DCs, indicated by upregulated IFN-γ in CD8+ T cells. Additionally, HMGB1 increased the accumulation of DCs by promoting CCR5 and CXCR3 production. Moreover, the resultant IFN-γ elevated the levels of HMGB1 and DC-associated chemokines, CCL5, CXCL10 and CXCL11 in tumor cells. Hence, the HMGB1-IFN-γ cycle may represent an important mechanism underlying DC-mediated anti-tumor immune response.

Original languageEnglish (US)
Article number103850
JournalCellular Immunology
Volume343
DOIs
StatePublished - Sep 1 2019

Fingerprint

HMGB1 Protein
Dendritic Cells
Interferons
Immunity
Neoplasms
Chemokine CXCL11
Lung Neoplasms
Chemokine CXCL10
T-Lymphocytes
Chemokine CCL5
HLA-DR Antigens
Messenger RNA

Keywords

  • CCL5
  • CCR5
  • CXCL10
  • CXCL11
  • CXCR3
  • Cytotoxic T lymphocyte
  • Dendritic cell
  • High-mobility group box 1
  • Interferon-γ

ASJC Scopus subject areas

  • Immunology

Cite this

Gao, Qun ; Li, Feng ; Wang, Shumin ; Shen, Z. ; Cheng, Shaoyan ; Ping, Yu ; Qin, Guohui ; Chen, Xinfeng ; Yang, Li ; Cao, Ling ; Liu, Shasha ; Zhang, Bin ; Wang, Liping ; Sun, Yan ; Zhang, Yi. / A cycle involving HMGB1, IFN-γ and dendritic cells plays a putative role in anti-tumor immunity. In: Cellular Immunology. 2019 ; Vol. 343.
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title = "A cycle involving HMGB1, IFN-γ and dendritic cells plays a putative role in anti-tumor immunity",
abstract = "An important subset in regulating antitumor immunity is the maturation and accumulation of intratumor dendritic cells (DCs), inducing potent T cell cytotoxicity. In this study, we explored how the soluble abundant high-mobility group box 1 protein (HMGB1) affected DC activation and retention within lung cancers, and in which way the resultant interferon-γ (IFN-γ) further enhanced DC maturation and accumulation. It was discovered that HMGB1 was correlated with DC markers HLA-DR and CD86 in lung cancers at both mRNA and protein level. Further analyses showed HMGB1 enhanced the maturation of DCs, indicated by upregulated IFN-γ in CD8+ T cells. Additionally, HMGB1 increased the accumulation of DCs by promoting CCR5 and CXCR3 production. Moreover, the resultant IFN-γ elevated the levels of HMGB1 and DC-associated chemokines, CCL5, CXCL10 and CXCL11 in tumor cells. Hence, the HMGB1-IFN-γ cycle may represent an important mechanism underlying DC-mediated anti-tumor immune response.",
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author = "Qun Gao and Feng Li and Shumin Wang and Z. Shen and Shaoyan Cheng and Yu Ping and Guohui Qin and Xinfeng Chen and Li Yang and Ling Cao and Shasha Liu and Bin Zhang and Liping Wang and Yan Sun and Yi Zhang",
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Gao, Q, Li, F, Wang, S, Shen, Z, Cheng, S, Ping, Y, Qin, G, Chen, X, Yang, L, Cao, L, Liu, S, Zhang, B, Wang, L, Sun, Y & Zhang, Y 2019, 'A cycle involving HMGB1, IFN-γ and dendritic cells plays a putative role in anti-tumor immunity', Cellular Immunology, vol. 343, 103850. https://doi.org/10.1016/j.cellimm.2018.08.011

A cycle involving HMGB1, IFN-γ and dendritic cells plays a putative role in anti-tumor immunity. / Gao, Qun; Li, Feng; Wang, Shumin; Shen, Z.; Cheng, Shaoyan; Ping, Yu; Qin, Guohui; Chen, Xinfeng; Yang, Li; Cao, Ling; Liu, Shasha; Zhang, Bin; Wang, Liping; Sun, Yan; Zhang, Yi.

In: Cellular Immunology, Vol. 343, 103850, 01.09.2019.

Research output: Contribution to journalArticle

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AU - Gao, Qun

AU - Li, Feng

AU - Wang, Shumin

AU - Shen, Z.

AU - Cheng, Shaoyan

AU - Ping, Yu

AU - Qin, Guohui

AU - Chen, Xinfeng

AU - Yang, Li

AU - Cao, Ling

AU - Liu, Shasha

AU - Zhang, Bin

AU - Wang, Liping

AU - Sun, Yan

AU - Zhang, Yi

PY - 2019/9/1

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N2 - An important subset in regulating antitumor immunity is the maturation and accumulation of intratumor dendritic cells (DCs), inducing potent T cell cytotoxicity. In this study, we explored how the soluble abundant high-mobility group box 1 protein (HMGB1) affected DC activation and retention within lung cancers, and in which way the resultant interferon-γ (IFN-γ) further enhanced DC maturation and accumulation. It was discovered that HMGB1 was correlated with DC markers HLA-DR and CD86 in lung cancers at both mRNA and protein level. Further analyses showed HMGB1 enhanced the maturation of DCs, indicated by upregulated IFN-γ in CD8+ T cells. Additionally, HMGB1 increased the accumulation of DCs by promoting CCR5 and CXCR3 production. Moreover, the resultant IFN-γ elevated the levels of HMGB1 and DC-associated chemokines, CCL5, CXCL10 and CXCL11 in tumor cells. Hence, the HMGB1-IFN-γ cycle may represent an important mechanism underlying DC-mediated anti-tumor immune response.

AB - An important subset in regulating antitumor immunity is the maturation and accumulation of intratumor dendritic cells (DCs), inducing potent T cell cytotoxicity. In this study, we explored how the soluble abundant high-mobility group box 1 protein (HMGB1) affected DC activation and retention within lung cancers, and in which way the resultant interferon-γ (IFN-γ) further enhanced DC maturation and accumulation. It was discovered that HMGB1 was correlated with DC markers HLA-DR and CD86 in lung cancers at both mRNA and protein level. Further analyses showed HMGB1 enhanced the maturation of DCs, indicated by upregulated IFN-γ in CD8+ T cells. Additionally, HMGB1 increased the accumulation of DCs by promoting CCR5 and CXCR3 production. Moreover, the resultant IFN-γ elevated the levels of HMGB1 and DC-associated chemokines, CCL5, CXCL10 and CXCL11 in tumor cells. Hence, the HMGB1-IFN-γ cycle may represent an important mechanism underlying DC-mediated anti-tumor immune response.

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