A DC-specific cytolytic T lymphocyte line is OKT8+

A. M. Krensky, C. Clayberger, J. L. Greenstein, M. Crimmins, S. J. Burakoff

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

A human cytotoxic T lymphocyte (CTL) line, A9, was generated by limiting dilution and was selected because of its apparent DC specificity. A9 is 100% OKT3+, 90% OKT4+, and 10% OKT8+, but by negative selection the CTL present are entirely OKT8+. These OKT8+ CTL are totally inhibitable by Genox 3.53, an anti-DC1 monoclonal antibody (mAb), and Leu-10, an anti-DC subgroup mAb, but are not inhibitable by a panel of anti-HLA-DR mAb. These CTL are also inhibitable by anti-OKT3 and anti-LFA-2 but not by OKT4 or OKT8 mAb. These findings extend previous studies that showed that OKT8+ CTL recognize HLA-A,B antigens, whereas OKT4+ CTL recognize HLA-DR and SB antigens. It is possible that an as yet undefined T cell surface molecule is involved in DC recognition.

Original languageEnglish (US)
Pages (from-to)2777-2780
Number of pages4
JournalJournal of Immunology
Volume131
Issue number6
StatePublished - 1983

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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