A deep penetrating facial congenital melanocytic tumor with bone involvement and ipsilateral eye blindness

Reuven Bergman*, Miriam W. Ben-Arush, Rachel Bar-Shalom, Michael Gilboa, Einav Simon, Dov Hershkovitz, Edmond Sabo, Alexander Maly, Pedram Gerami, Dorith Goldsher

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Bone involvement has been described in tumors with melanocytic differentiation such as melanotic neuroectodermal tumor of infancy, and very rarely in cellular blue nevi and neurocristic cutaneous hamartoma. We present an unusual case of facial congenital melanocytic tumor that involved the underlying bones and maxillary sinus and led to unilateral blindness. A newborn with a large red bluish patch with peripheral brown and black macules overlying marked swelling on the left side of his face was presented. The tumor was shown by magnetic resonance imaging, scintigraphy, and histopathology to invade the underlying bones and maxillary sinus and to compress the left eyeball resulting in blindness. Histopathology, immunohistochemistry, morphometric computerized microscopy, molecular genetic mutation analysis, and fluorescent in situ hybridization studies were more congruent with a melanocytic nevus. An 8.5-year follow-up was uneventful, with spontaneous partial shrinkage of the tumor.

Original languageEnglish (US)
Pages (from-to)e5-e11
JournalAmerican Journal of Dermatopathology
Volume37
Issue number1
DOIs
StatePublished - Jan 1 2015

Keywords

  • Bone
  • Congenital
  • Eye
  • Melanocytic
  • Nevus

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology

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