A description of the methods of the Nulliparous Pregnancy Outcomes Study

Monitoring mothers-to-be (nuMoM2b)

David M. Haas*, Corette B. Parker, Deborah A. Wing, Samuel Parry, William A Grobman, Brian M. Mercer, Hyagriv N. Simhan, Matthew K. Hoffman, Robert M. Silver, Pathik Wadhwa, Jay D. Iams, Matthew A. Koch, Steve N. Caritis, Ronald J. Wapner, M. Sean Esplin, Michal A. Elovitz, Tatiana Foroud, Alan M Peaceman, George R. Saade, Marian Willinger & 1 others Uma M. Reddy

*Corresponding author for this work

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Objective The primary aim of the "Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be" is to determine maternal characteristics, which include genetic, physiologic response to pregnancy, and environmental factors that predict adverse pregnancy outcomes. Study Design Nulliparous women in the first trimester of pregnancy were recruited into an observational cohort study. Participants were seen at 3 study visits during pregnancy and again at delivery. We collected data from in-clinic interviews, take-home surveys, clinical measurements, ultrasound studies, and chart abstractions. Maternal biospecimens (serum, plasma, urine, cervicovaginal fluid) at antepartum study visits and delivery specimens (placenta, umbilical cord, cord blood) were collected, processed, and stored. The primary outcome of the study was defined as pregnancy ending at <37+0 weeks' gestation. Key study hypotheses involve adverse pregnancy outcomes of spontaneous preterm birth, preeclampsia, and fetal growth restriction. Results We recruited 10,037 women to the study. Basic characteristics of the cohort at screening are reported. Conclusion The "Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be" cohort study methods and procedures can help investigators when they plan future projects.

Original languageEnglish (US)
Pages (from-to)539.e1-539.e24
JournalAmerican journal of obstetrics and gynecology
Volume212
Issue number4
DOIs
StatePublished - Apr 1 2015

Fingerprint

Pregnancy Outcome
Mothers
Outcome Assessment (Health Care)
Pregnancy
Cohort Studies
Umbilical Cord
Premature Birth
First Pregnancy Trimester
Fetal Development
Pre-Eclampsia
Fetal Blood
Placenta
Observational Studies
Research Personnel
Urine
Interviews
Serum

Keywords

  • adverse pregnancy outcome
  • cohort study
  • methods
  • nulliparous
  • prediction
  • pregnancy
  • psychosocial

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Haas, David M. ; Parker, Corette B. ; Wing, Deborah A. ; Parry, Samuel ; Grobman, William A ; Mercer, Brian M. ; Simhan, Hyagriv N. ; Hoffman, Matthew K. ; Silver, Robert M. ; Wadhwa, Pathik ; Iams, Jay D. ; Koch, Matthew A. ; Caritis, Steve N. ; Wapner, Ronald J. ; Esplin, M. Sean ; Elovitz, Michal A. ; Foroud, Tatiana ; Peaceman, Alan M ; Saade, George R. ; Willinger, Marian ; Reddy, Uma M. / A description of the methods of the Nulliparous Pregnancy Outcomes Study : Monitoring mothers-to-be (nuMoM2b). In: American journal of obstetrics and gynecology. 2015 ; Vol. 212, No. 4. pp. 539.e1-539.e24.
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abstract = "Objective The primary aim of the {"}Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be{"} is to determine maternal characteristics, which include genetic, physiologic response to pregnancy, and environmental factors that predict adverse pregnancy outcomes. Study Design Nulliparous women in the first trimester of pregnancy were recruited into an observational cohort study. Participants were seen at 3 study visits during pregnancy and again at delivery. We collected data from in-clinic interviews, take-home surveys, clinical measurements, ultrasound studies, and chart abstractions. Maternal biospecimens (serum, plasma, urine, cervicovaginal fluid) at antepartum study visits and delivery specimens (placenta, umbilical cord, cord blood) were collected, processed, and stored. The primary outcome of the study was defined as pregnancy ending at <37+0 weeks' gestation. Key study hypotheses involve adverse pregnancy outcomes of spontaneous preterm birth, preeclampsia, and fetal growth restriction. Results We recruited 10,037 women to the study. Basic characteristics of the cohort at screening are reported. Conclusion The {"}Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be{"} cohort study methods and procedures can help investigators when they plan future projects.",
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author = "Haas, {David M.} and Parker, {Corette B.} and Wing, {Deborah A.} and Samuel Parry and Grobman, {William A} and Mercer, {Brian M.} and Simhan, {Hyagriv N.} and Hoffman, {Matthew K.} and Silver, {Robert M.} and Pathik Wadhwa and Iams, {Jay D.} and Koch, {Matthew A.} and Caritis, {Steve N.} and Wapner, {Ronald J.} and Esplin, {M. Sean} and Elovitz, {Michal A.} and Tatiana Foroud and Peaceman, {Alan M} and Saade, {George R.} and Marian Willinger and Reddy, {Uma M.}",
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Haas, DM, Parker, CB, Wing, DA, Parry, S, Grobman, WA, Mercer, BM, Simhan, HN, Hoffman, MK, Silver, RM, Wadhwa, P, Iams, JD, Koch, MA, Caritis, SN, Wapner, RJ, Esplin, MS, Elovitz, MA, Foroud, T, Peaceman, AM, Saade, GR, Willinger, M & Reddy, UM 2015, 'A description of the methods of the Nulliparous Pregnancy Outcomes Study: Monitoring mothers-to-be (nuMoM2b)', American journal of obstetrics and gynecology, vol. 212, no. 4, pp. 539.e1-539.e24. https://doi.org/10.1016/j.ajog.2015.01.019

A description of the methods of the Nulliparous Pregnancy Outcomes Study : Monitoring mothers-to-be (nuMoM2b). / Haas, David M.; Parker, Corette B.; Wing, Deborah A.; Parry, Samuel; Grobman, William A; Mercer, Brian M.; Simhan, Hyagriv N.; Hoffman, Matthew K.; Silver, Robert M.; Wadhwa, Pathik; Iams, Jay D.; Koch, Matthew A.; Caritis, Steve N.; Wapner, Ronald J.; Esplin, M. Sean; Elovitz, Michal A.; Foroud, Tatiana; Peaceman, Alan M; Saade, George R.; Willinger, Marian; Reddy, Uma M.

In: American journal of obstetrics and gynecology, Vol. 212, No. 4, 01.04.2015, p. 539.e1-539.e24.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A description of the methods of the Nulliparous Pregnancy Outcomes Study

T2 - Monitoring mothers-to-be (nuMoM2b)

AU - Haas, David M.

AU - Parker, Corette B.

AU - Wing, Deborah A.

AU - Parry, Samuel

AU - Grobman, William A

AU - Mercer, Brian M.

AU - Simhan, Hyagriv N.

AU - Hoffman, Matthew K.

AU - Silver, Robert M.

AU - Wadhwa, Pathik

AU - Iams, Jay D.

AU - Koch, Matthew A.

AU - Caritis, Steve N.

AU - Wapner, Ronald J.

AU - Esplin, M. Sean

AU - Elovitz, Michal A.

AU - Foroud, Tatiana

AU - Peaceman, Alan M

AU - Saade, George R.

AU - Willinger, Marian

AU - Reddy, Uma M.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Objective The primary aim of the "Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be" is to determine maternal characteristics, which include genetic, physiologic response to pregnancy, and environmental factors that predict adverse pregnancy outcomes. Study Design Nulliparous women in the first trimester of pregnancy were recruited into an observational cohort study. Participants were seen at 3 study visits during pregnancy and again at delivery. We collected data from in-clinic interviews, take-home surveys, clinical measurements, ultrasound studies, and chart abstractions. Maternal biospecimens (serum, plasma, urine, cervicovaginal fluid) at antepartum study visits and delivery specimens (placenta, umbilical cord, cord blood) were collected, processed, and stored. The primary outcome of the study was defined as pregnancy ending at <37+0 weeks' gestation. Key study hypotheses involve adverse pregnancy outcomes of spontaneous preterm birth, preeclampsia, and fetal growth restriction. Results We recruited 10,037 women to the study. Basic characteristics of the cohort at screening are reported. Conclusion The "Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be" cohort study methods and procedures can help investigators when they plan future projects.

AB - Objective The primary aim of the "Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be" is to determine maternal characteristics, which include genetic, physiologic response to pregnancy, and environmental factors that predict adverse pregnancy outcomes. Study Design Nulliparous women in the first trimester of pregnancy were recruited into an observational cohort study. Participants were seen at 3 study visits during pregnancy and again at delivery. We collected data from in-clinic interviews, take-home surveys, clinical measurements, ultrasound studies, and chart abstractions. Maternal biospecimens (serum, plasma, urine, cervicovaginal fluid) at antepartum study visits and delivery specimens (placenta, umbilical cord, cord blood) were collected, processed, and stored. The primary outcome of the study was defined as pregnancy ending at <37+0 weeks' gestation. Key study hypotheses involve adverse pregnancy outcomes of spontaneous preterm birth, preeclampsia, and fetal growth restriction. Results We recruited 10,037 women to the study. Basic characteristics of the cohort at screening are reported. Conclusion The "Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be" cohort study methods and procedures can help investigators when they plan future projects.

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KW - cohort study

KW - methods

KW - nulliparous

KW - prediction

KW - pregnancy

KW - psychosocial

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