A description of the methods of the Nulliparous Pregnancy Outcomes Study: Monitoring mothers-to-be (nuMoM2b)

David M. Haas; Corette B. Parker; Deborah A. Wing; Samuel Parry; William A. Grobman; Brian M. Mercer; Hyagriv N. Simhan; Matthew K. Hoffman; Robert M. Silver; Pathik Wadhwa; Jay D. Iams; Matthew A. Koch; Steve N. Caritis; Ronald J. Wapner; M. Sean Esplin; Michal A. Elovitz; Tatiana Foroud; Alan M. Peaceman; George R. Saade; Marian Willinger; Uma M. Reddy

doi:10.1016/j.ajog.2015.01.019

A description of the methods of the Nulliparous Pregnancy Outcomes Study: Monitoring mothers-to-be (nuMoM2b)

David M. Haas^*, Corette B. Parker, Deborah A. Wing, Samuel Parry, William A. Grobman, Brian M. Mercer, Hyagriv N. Simhan, Matthew K. Hoffman, Robert M. Silver, Pathik Wadhwa, Jay D. Iams, Matthew A. Koch, Steve N. Caritis, Ronald J. Wapner, M. Sean Esplin, Michal A. Elovitz, Tatiana Foroud, Alan M. Peaceman, George R. Saade, Marian WillingerUma M. Reddy

^*Corresponding author for this work

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

177 Scopus citations

Abstract

Objective The primary aim of the "Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be" is to determine maternal characteristics, which include genetic, physiologic response to pregnancy, and environmental factors that predict adverse pregnancy outcomes. Study Design Nulliparous women in the first trimester of pregnancy were recruited into an observational cohort study. Participants were seen at 3 study visits during pregnancy and again at delivery. We collected data from in-clinic interviews, take-home surveys, clinical measurements, ultrasound studies, and chart abstractions. Maternal biospecimens (serum, plasma, urine, cervicovaginal fluid) at antepartum study visits and delivery specimens (placenta, umbilical cord, cord blood) were collected, processed, and stored. The primary outcome of the study was defined as pregnancy ending at <37+0 weeks' gestation. Key study hypotheses involve adverse pregnancy outcomes of spontaneous preterm birth, preeclampsia, and fetal growth restriction. Results We recruited 10,037 women to the study. Basic characteristics of the cohort at screening are reported. Conclusion The "Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be" cohort study methods and procedures can help investigators when they plan future projects.

Original language	English (US)
Pages (from-to)	539.e1-539.e24
Journal	American journal of obstetrics and gynecology
Volume	212
Issue number	4
DOIs	https://doi.org/10.1016/j.ajog.2015.01.019
State	Published - Apr 1 2015

Funding

Supported by grant funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development : U10 HD063036 , RTI International ; U10 HD063072 , Case Western Reserve University ; U10 HD063047 , Columbia University ; U10 HD063037 , Indiana University ; U10 HD063041 , University of Pittsburgh ; U10 HD063020 , Northwestern University ; U10 HD063046 , University of California Irvine ; U10 HD063048 , University of Pennsylvania ; and U10 HD063053 , University of Utah . In addition, support was provided by respective Clinical and Translational Science Institutes to Indiana University (UL1TR001108) and University of California Irvine (UL1TR000153).

Keywords

adverse pregnancy outcome
cohort study
methods
nulliparous
prediction
pregnancy
psychosocial

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1016/j.ajog.2015.01.019

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Haas, D. M., Parker, C. B., Wing, D. A., Parry, S., Grobman, W. A., Mercer, B. M., Simhan, H. N., Hoffman, M. K., Silver, R. M., Wadhwa, P., Iams, J. D., Koch, M. A., Caritis, S. N., Wapner, R. J., Esplin, M. S., Elovitz, M. A., Foroud, T., Peaceman, A. M., Saade, G. R., ... Reddy, U. M. (2015). A description of the methods of the Nulliparous Pregnancy Outcomes Study: Monitoring mothers-to-be (nuMoM2b). American journal of obstetrics and gynecology, 212(4), 539.e1-539.e24. https://doi.org/10.1016/j.ajog.2015.01.019

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title = "A description of the methods of the Nulliparous Pregnancy Outcomes Study: Monitoring mothers-to-be (nuMoM2b)",

abstract = "Objective The primary aim of the {"}Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be{"} is to determine maternal characteristics, which include genetic, physiologic response to pregnancy, and environmental factors that predict adverse pregnancy outcomes. Study Design Nulliparous women in the first trimester of pregnancy were recruited into an observational cohort study. Participants were seen at 3 study visits during pregnancy and again at delivery. We collected data from in-clinic interviews, take-home surveys, clinical measurements, ultrasound studies, and chart abstractions. Maternal biospecimens (serum, plasma, urine, cervicovaginal fluid) at antepartum study visits and delivery specimens (placenta, umbilical cord, cord blood) were collected, processed, and stored. The primary outcome of the study was defined as pregnancy ending at <37+0 weeks' gestation. Key study hypotheses involve adverse pregnancy outcomes of spontaneous preterm birth, preeclampsia, and fetal growth restriction. Results We recruited 10,037 women to the study. Basic characteristics of the cohort at screening are reported. Conclusion The {"}Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be{"} cohort study methods and procedures can help investigators when they plan future projects.",

keywords = "adverse pregnancy outcome, cohort study, methods, nulliparous, prediction, pregnancy, psychosocial",

author = "Haas, {David M.} and Parker, {Corette B.} and Wing, {Deborah A.} and Samuel Parry and Grobman, {William A.} and Mercer, {Brian M.} and Simhan, {Hyagriv N.} and Hoffman, {Matthew K.} and Silver, {Robert M.} and Pathik Wadhwa and Iams, {Jay D.} and Koch, {Matthew A.} and Caritis, {Steve N.} and Wapner, {Ronald J.} and Esplin, {M. Sean} and Elovitz, {Michal A.} and Tatiana Foroud and Peaceman, {Alan M.} and Saade, {George R.} and Marian Willinger and Reddy, {Uma M.}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

year = "2015",

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day = "1",

doi = "10.1016/j.ajog.2015.01.019",

language = "English (US)",

volume = "212",

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Haas, DM, Parker, CB, Wing, DA, Parry, S, Grobman, WA, Mercer, BM, Simhan, HN, Hoffman, MK, Silver, RM, Wadhwa, P, Iams, JD, Koch, MA, Caritis, SN, Wapner, RJ, Esplin, MS, Elovitz, MA, Foroud, T, Peaceman, AM, Saade, GR, Willinger, M & Reddy, UM 2015, 'A description of the methods of the Nulliparous Pregnancy Outcomes Study: Monitoring mothers-to-be (nuMoM2b)', American journal of obstetrics and gynecology, vol. 212, no. 4, pp. 539.e1-539.e24. https://doi.org/10.1016/j.ajog.2015.01.019

TY - JOUR

T1 - A description of the methods of the Nulliparous Pregnancy Outcomes Study

T2 - Monitoring mothers-to-be (nuMoM2b)

AU - Haas, David M.

AU - Parker, Corette B.

AU - Wing, Deborah A.

AU - Parry, Samuel

AU - Grobman, William A.

AU - Mercer, Brian M.

AU - Simhan, Hyagriv N.

AU - Hoffman, Matthew K.

AU - Silver, Robert M.

AU - Wadhwa, Pathik

AU - Iams, Jay D.

AU - Koch, Matthew A.

AU - Caritis, Steve N.

AU - Wapner, Ronald J.

AU - Esplin, M. Sean

AU - Elovitz, Michal A.

AU - Foroud, Tatiana

AU - Peaceman, Alan M.

AU - Saade, George R.

AU - Willinger, Marian

AU - Reddy, Uma M.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Objective The primary aim of the "Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be" is to determine maternal characteristics, which include genetic, physiologic response to pregnancy, and environmental factors that predict adverse pregnancy outcomes. Study Design Nulliparous women in the first trimester of pregnancy were recruited into an observational cohort study. Participants were seen at 3 study visits during pregnancy and again at delivery. We collected data from in-clinic interviews, take-home surveys, clinical measurements, ultrasound studies, and chart abstractions. Maternal biospecimens (serum, plasma, urine, cervicovaginal fluid) at antepartum study visits and delivery specimens (placenta, umbilical cord, cord blood) were collected, processed, and stored. The primary outcome of the study was defined as pregnancy ending at <37+0 weeks' gestation. Key study hypotheses involve adverse pregnancy outcomes of spontaneous preterm birth, preeclampsia, and fetal growth restriction. Results We recruited 10,037 women to the study. Basic characteristics of the cohort at screening are reported. Conclusion The "Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be" cohort study methods and procedures can help investigators when they plan future projects.

AB - Objective The primary aim of the "Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be" is to determine maternal characteristics, which include genetic, physiologic response to pregnancy, and environmental factors that predict adverse pregnancy outcomes. Study Design Nulliparous women in the first trimester of pregnancy were recruited into an observational cohort study. Participants were seen at 3 study visits during pregnancy and again at delivery. We collected data from in-clinic interviews, take-home surveys, clinical measurements, ultrasound studies, and chart abstractions. Maternal biospecimens (serum, plasma, urine, cervicovaginal fluid) at antepartum study visits and delivery specimens (placenta, umbilical cord, cord blood) were collected, processed, and stored. The primary outcome of the study was defined as pregnancy ending at <37+0 weeks' gestation. Key study hypotheses involve adverse pregnancy outcomes of spontaneous preterm birth, preeclampsia, and fetal growth restriction. Results We recruited 10,037 women to the study. Basic characteristics of the cohort at screening are reported. Conclusion The "Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be" cohort study methods and procedures can help investigators when they plan future projects.

KW - adverse pregnancy outcome

KW - cohort study

KW - methods

KW - nulliparous

KW - prediction

KW - pregnancy

KW - psychosocial

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AN - SCOPUS:84930415809

SN - 0002-9378

VL - 212

SP - 539.e1-539.e24

JO - American journal of obstetrics and gynecology

JF - American journal of obstetrics and gynecology

IS - 4

ER -

A description of the methods of the Nulliparous Pregnancy Outcomes Study: Monitoring mothers-to-be (nuMoM2b)

Abstract

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Keywords

ASJC Scopus subject areas

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