A direct method for measuring surface area of polymer mesh using synchrotron x-radiation microComputed tomography: A pilot study

Sumanas W. Jordan*, Lindsay E. Janes, Rachita Sood, Adam E. Jakus, Carmen Soriano, Stuart R. Stock, Gregory A. Dumanian

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Mesh products are critical for successful long term surgical repair of many anatomic defects, including hernias and pelvic prolapse. Biocompatibility of polymeric mesh depends on the foreign body response-how the tissues react to physicochemical properties, including porosity and mesh 'weight'. We postulate that effective surface area, the total filament area in contact with the tissues, is an important variable for long-Term repair strength. We present a technique utilizing synchrotron x-radiation microComputed Tomography (microCT) to calculate the effective surface area of polymeric meshes. Six representative polypropylene-based hernia meshes, including composite meshes, were studied: Ethicon PROLENETM, Ethicon PROLENETM Soft Mesh, Ethicon PHYSIOMESH TM, Ethicon ULTRAPROTM, Atrium PROLITETM Mesh, and Bard® Soft Mesh. Ethicon PROLENETM, a heavy weight mesh, had the highest effective surface area at 6.44 cm2 cm-2 and Ethicon ULTRAPROTM, a composite light-weight mesh, had the lowest effective surface area at 0.62 cm2 cm-2. We conclude that this technique can reliably be used to further classify mesh, as manufacturers and surgeons continue to optimize the safety profile of these implants.

Original languageEnglish (US)
Article number067001
JournalBiomedical Physics and Engineering Express
Volume5
Issue number6
DOIs
StatePublished - Sep 25 2019

Keywords

  • bio-compatibility
  • foreign body response
  • mesh
  • microCT
  • surface area

ASJC Scopus subject areas

  • Nursing(all)

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