A dLight-ful New View of Neuromodulation

Caitlin V. Cosme; Gates K. Palissery; Talia N. Lerner

doi:10.1016/j.tins.2018.07.004

A dLight-ful New View of Neuromodulation

Caitlin V. Cosme, Gates K. Palissery, Talia N. Lerner^*

^*Corresponding author for this work

Neuroscience

Research output: Contribution to journal › Short survey › peer-review

6 Scopus citations

Abstract

Neuromodulators such as dopamine can transform neural circuit function, but the mechanisms underlying such transformations are incompletely understood. A recent study introduced dLight1, a genetically encoded fluorescent dopamine indicator. dLight1 allows the optical measurement of dopamine sensed by isolated target circuits with high spatiotemporal resolution and has unique advantages for the study of neuromodulatory mechanisms.

Original language	English (US)
Pages (from-to)	566-568
Number of pages	3
Journal	Trends in Neurosciences
Volume	41
Issue number	9
DOIs	https://doi.org/10.1016/j.tins.2018.07.004
State	Published - Sep 2018

Keywords

dopamine
genetically encoded indicators
imaging
neuromodulation

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.tins.2018.07.004

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title = "A dLight-ful New View of Neuromodulation",

abstract = "Neuromodulators such as dopamine can transform neural circuit function, but the mechanisms underlying such transformations are incompletely understood. A recent study introduced dLight1, a genetically encoded fluorescent dopamine indicator. dLight1 allows the optical measurement of dopamine sensed by isolated target circuits with high spatiotemporal resolution and has unique advantages for the study of neuromodulatory mechanisms.",

keywords = "dopamine, genetically encoded indicators, imaging, neuromodulation",

author = "Cosme, {Caitlin V.} and Palissery, {Gates K.} and Lerner, {Talia N.}",

note = "Funding Information: Work in the Lerner laboratory is supported by Northwestern University , Searle Funds at The Chicago Community Trust, the National Institute of Mental Health ( R00 MH109569 ), and the Brain & Behavior Research Foundation (NARSAD Young Investigator Grant). Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

year = "2018",

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doi = "10.1016/j.tins.2018.07.004",

language = "English (US)",

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journal = "Trends in Neurosciences",

issn = "0166-2236",

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TY - JOUR

T1 - A dLight-ful New View of Neuromodulation

AU - Cosme, Caitlin V.

AU - Palissery, Gates K.

AU - Lerner, Talia N.

N1 - Funding Information: Work in the Lerner laboratory is supported by Northwestern University , Searle Funds at The Chicago Community Trust, the National Institute of Mental Health ( R00 MH109569 ), and the Brain & Behavior Research Foundation (NARSAD Young Investigator Grant). Publisher Copyright: © 2018 Elsevier Ltd

PY - 2018/9

Y1 - 2018/9

N2 - Neuromodulators such as dopamine can transform neural circuit function, but the mechanisms underlying such transformations are incompletely understood. A recent study introduced dLight1, a genetically encoded fluorescent dopamine indicator. dLight1 allows the optical measurement of dopamine sensed by isolated target circuits with high spatiotemporal resolution and has unique advantages for the study of neuromodulatory mechanisms.

AB - Neuromodulators such as dopamine can transform neural circuit function, but the mechanisms underlying such transformations are incompletely understood. A recent study introduced dLight1, a genetically encoded fluorescent dopamine indicator. dLight1 allows the optical measurement of dopamine sensed by isolated target circuits with high spatiotemporal resolution and has unique advantages for the study of neuromodulatory mechanisms.

KW - dopamine

KW - genetically encoded indicators

KW - imaging

KW - neuromodulation

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U2 - 10.1016/j.tins.2018.07.004

DO - 10.1016/j.tins.2018.07.004

M3 - Short survey

C2 - 30055832

AN - SCOPUS:85050343351

SN - 0166-2236

VL - 41

SP - 566

EP - 568

JO - Trends in Neurosciences

JF - Trends in Neurosciences

IS - 9

ER -

A dLight-ful New View of Neuromodulation

Abstract

Keywords

ASJC Scopus subject areas

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