A dLight-ful New View of Neuromodulation

Caitlin V. Cosme, Gates K. Palissery, Talia Newcombe Lerner*

*Corresponding author for this work

Research output: Contribution to journalShort survey

Abstract

Neuromodulators such as dopamine can transform neural circuit function, but the mechanisms underlying such transformations are incompletely understood. A recent study introduced dLight1, a genetically encoded fluorescent dopamine indicator. dLight1 allows the optical measurement of dopamine sensed by isolated target circuits with high spatiotemporal resolution and has unique advantages for the study of neuromodulatory mechanisms.

Original languageEnglish (US)
Pages (from-to)566-568
Number of pages3
JournalTrends in Neurosciences
Volume41
Issue number9
DOIs
StatePublished - Sep 1 2018

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Dopamine
Neurotransmitter Agents
Wolfiporia

Keywords

  • dopamine
  • genetically encoded indicators
  • imaging
  • neuromodulation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cosme, Caitlin V. ; Palissery, Gates K. ; Lerner, Talia Newcombe. / A dLight-ful New View of Neuromodulation. In: Trends in Neurosciences. 2018 ; Vol. 41, No. 9. pp. 566-568.
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A dLight-ful New View of Neuromodulation. / Cosme, Caitlin V.; Palissery, Gates K.; Lerner, Talia Newcombe.

In: Trends in Neurosciences, Vol. 41, No. 9, 01.09.2018, p. 566-568.

Research output: Contribution to journalShort survey

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AU - Cosme, Caitlin V.

AU - Palissery, Gates K.

AU - Lerner, Talia Newcombe

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AB - Neuromodulators such as dopamine can transform neural circuit function, but the mechanisms underlying such transformations are incompletely understood. A recent study introduced dLight1, a genetically encoded fluorescent dopamine indicator. dLight1 allows the optical measurement of dopamine sensed by isolated target circuits with high spatiotemporal resolution and has unique advantages for the study of neuromodulatory mechanisms.

KW - dopamine

KW - genetically encoded indicators

KW - imaging

KW - neuromodulation

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