A double-blind comparison of clovoxamine and amitriptyline in the treatment of depressed outpatients

Alan J. Gelenberg*, Joanne D. Wojcik, Christine Newell, Donna L. Lamping, Bonnie Spring

*Corresponding author for this work

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Forty-two outpatients with major depression were treated in a 4-week double-blind parallelgroup comparison of the new antidepressant clovoxamine—a member of oximethers of aralkylketones—with amitriptyline. The two drugs were comparable in efficacy, although because of the small sample size a moderate clinical difference between treatments may not have been detected. The magnitude of unwanted effects also was comparable, but clovoxamine produced fewer “anticholinergic” effects; this was determined by patient complaints of typical anticholinergic symptoms, by decreased salivary flow, and by a new signal detection memory test.

Original languageEnglish (US)
Pages (from-to)30-34
Number of pages5
JournalJournal of Clinical Psychopharmacology
Volume5
Issue number1
StatePublished - Jan 1 1985

Fingerprint

Amitriptyline
Cholinergic Antagonists
Outpatients
Sample Size
Antidepressive Agents
Depression
Therapeutics
Pharmaceutical Preparations
clovoxamine
Psychological Signal Detection

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Psychiatry and Mental health
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Gelenberg, Alan J. ; Wojcik, Joanne D. ; Newell, Christine ; Lamping, Donna L. ; Spring, Bonnie. / A double-blind comparison of clovoxamine and amitriptyline in the treatment of depressed outpatients. In: Journal of Clinical Psychopharmacology. 1985 ; Vol. 5, No. 1. pp. 30-34.
@article{78d197ed0d284b39b8b95ac2fcf2d4e2,
title = "A double-blind comparison of clovoxamine and amitriptyline in the treatment of depressed outpatients",
abstract = "Forty-two outpatients with major depression were treated in a 4-week double-blind parallelgroup comparison of the new antidepressant clovoxamine—a member of oximethers of aralkylketones—with amitriptyline. The two drugs were comparable in efficacy, although because of the small sample size a moderate clinical difference between treatments may not have been detected. The magnitude of unwanted effects also was comparable, but clovoxamine produced fewer “anticholinergic” effects; this was determined by patient complaints of typical anticholinergic symptoms, by decreased salivary flow, and by a new signal detection memory test.",
author = "Gelenberg, {Alan J.} and Wojcik, {Joanne D.} and Christine Newell and Lamping, {Donna L.} and Bonnie Spring",
year = "1985",
month = "1",
day = "1",
language = "English (US)",
volume = "5",
pages = "30--34",
journal = "Journal of Clinical Psychopharmacology",
issn = "0271-0749",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

A double-blind comparison of clovoxamine and amitriptyline in the treatment of depressed outpatients. / Gelenberg, Alan J.; Wojcik, Joanne D.; Newell, Christine; Lamping, Donna L.; Spring, Bonnie.

In: Journal of Clinical Psychopharmacology, Vol. 5, No. 1, 01.01.1985, p. 30-34.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A double-blind comparison of clovoxamine and amitriptyline in the treatment of depressed outpatients

AU - Gelenberg, Alan J.

AU - Wojcik, Joanne D.

AU - Newell, Christine

AU - Lamping, Donna L.

AU - Spring, Bonnie

PY - 1985/1/1

Y1 - 1985/1/1

N2 - Forty-two outpatients with major depression were treated in a 4-week double-blind parallelgroup comparison of the new antidepressant clovoxamine—a member of oximethers of aralkylketones—with amitriptyline. The two drugs were comparable in efficacy, although because of the small sample size a moderate clinical difference between treatments may not have been detected. The magnitude of unwanted effects also was comparable, but clovoxamine produced fewer “anticholinergic” effects; this was determined by patient complaints of typical anticholinergic symptoms, by decreased salivary flow, and by a new signal detection memory test.

AB - Forty-two outpatients with major depression were treated in a 4-week double-blind parallelgroup comparison of the new antidepressant clovoxamine—a member of oximethers of aralkylketones—with amitriptyline. The two drugs were comparable in efficacy, although because of the small sample size a moderate clinical difference between treatments may not have been detected. The magnitude of unwanted effects also was comparable, but clovoxamine produced fewer “anticholinergic” effects; this was determined by patient complaints of typical anticholinergic symptoms, by decreased salivary flow, and by a new signal detection memory test.

UR - http://www.scopus.com/inward/record.url?scp=0021927297&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021927297&partnerID=8YFLogxK

M3 - Article

VL - 5

SP - 30

EP - 34

JO - Journal of Clinical Psychopharmacology

JF - Journal of Clinical Psychopharmacology

SN - 0271-0749

IS - 1

ER -