A double-blind comparison of clovoxamine and amitriptyline in the treatment of depressed outpatients

Alan J. Gelenberg*, Joanne D. Wojcik, Christine Newell, Donna L. Lamping, Bonnie Spring

*Corresponding author for this work

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Forty-two outpatients with major depression were treated in a 4-week double-blind parallelgroup comparison of the new antidepressant clovoxamine—a member of oximethers of aralkylketones—with amitriptyline. The two drugs were comparable in efficacy, although because of the small sample size a moderate clinical difference between treatments may not have been detected. The magnitude of unwanted effects also was comparable, but clovoxamine produced fewer “anticholinergic” effects; this was determined by patient complaints of typical anticholinergic symptoms, by decreased salivary flow, and by a new signal detection memory test.

Original languageEnglish (US)
Pages (from-to)30-34
Number of pages5
JournalJournal of clinical psychopharmacology
Volume5
Issue number1
DOIs
StatePublished - Feb 1985

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)

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