A dynamic network perspective of chronic pain

Melissa A. Farmer, Marwan N. Baliki, A. Vania Apkarian*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

137 Scopus citations


We briefly summarize recent advances regarding brain functional representation of chronic pain, reorganization of resting state brain activity, and of brain anatomy with chronic pain. Based on these observations and recent theoretical advances regarding network architecture properties, we develop a general concept of the dynamic interplay between anatomy and function as the brain progresses into persistent pain, and outline the role of mesolimbic learning mechanisms that are likely involved in maintenance of chronic pain.

Original languageEnglish (US)
Pages (from-to)197-203
Number of pages7
JournalNeuroscience Letters
Issue number2
StatePublished - Jun 29 2012


  • Chronic pain
  • Diffusion tensor imaging
  • Functional magnetic resonance imaging
  • Learning
  • Network
  • Neuroplasticity

ASJC Scopus subject areas

  • Neuroscience(all)


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