@article{64961c6c964e41c897fdb711f13188dc,
title = "A dynamic role for the mushroom bodies in promoting sleep in Drosophila",
abstract = "The fruitfly, Drosophila melanogaster, exhibits many of the cardinal features of sleep, yet little is known about the neural circuits governing its sleep. Here we have performed a screen of GAL4 lines expressing a temperature-sensitive synaptic blocker shibirets1 (ref. 2) in a range of discrete neural circuits, and assayed the amount of sleep at different temperatures. We identified three short-sleep lines at the restrictive temperature with shared expression in the mushroom bodies, a neural locus central to learning and memory. Chemical ablation of the mushroom bodies also resulted in reduced sleep. These studies highlight a central role for the mushroom bodies in sleep regulation.",
author = "Pitman, {Jena L.} and McGill, {Jermaine J.} and Keegan, {Kevin P.} and Ravi Allada",
note = "Funding Information: Acknowledgements We thank M. Villar, A. Schroeder, B. Finn, D. Hanrahan, A. Majeed and A. Phillips for assistance with PCR genotyping (M.V.), confocal imaging (A.S., B.F.), initial screening (D.H., A.M.) and designing data analysis software (A.P.); C. Cirelli and G. Tononi and their laboratories for advice on mechanical sleep deprivation; P. Shaw, T. Zars, M. Rosbash and E. Smith for comments; and B. Joiner and A. Sehgal for communicating results before publication. This work was supported by a Burroughs Wellcome Career Award in the Biomedical Sciences and by the NIH (R.A.). Copyright: Copyright 2015 Elsevier B.V., All rights reserved.",
year = "2006",
month = jun,
day = "8",
doi = "10.1038/nature04739",
language = "English (US)",
volume = "441",
pages = "753--756",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "7094",
}