A Family Focused Intervention Influences Hippocampal-Prefrontal Connectivity Through Gains in Self-Regulation

Jamie L. Hanson; Alysha D. Gillmore; Tianyi Yu; Christopher J. Holmes; Emily S. Hallowell; Allen W. Barton; Steven R.H. Beach; Adrianna Galván; James MacKillop; Michael Windle; Edith Chen; Gregory E. Miller; Lawrence H. Sweet; Gene H. Brody

doi:10.1111/cdev.13154

A Family Focused Intervention Influences Hippocampal-Prefrontal Connectivity Through Gains in Self-Regulation

Jamie L. Hanson^*, Alysha D. Gillmore, Tianyi Yu, Christopher J. Holmes, Emily S. Hallowell, Allen W. Barton, Steven R.H. Beach, Adrianna Galván, James MacKillop, Michael Windle, Edith Chen, Gregory E. Miller, Lawrence H. Sweet, Gene H. Brody

^*Corresponding author for this work

Psychology

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

The stressors associated with poverty increase the risks for externalizing psychopathology; however, specific patterns of neurobiology and higher self-regulation may buffer against these effects. This study leveraged a randomized control trial, aimed at increasing self-regulation at ~11 years of age. As adults, these same individuals completed functional MRI scanning (M_age = 24.88 years; intervention n = 44; control n = 49). Functional connectivity between the hippocampus and ventromedial prefrontal cortex was examined in relation to the intervention, gains in self-regulation, and present-day externalizing symptoms. Increased connectivity between these brain areas was noted in the intervention group compared to controls. Furthermore, individual gains in self-regulation, instilled by the intervention, statistically explained this brain difference. These results begin to connect neurobiological and psychosocial markers of risk and resiliency.

Original language	English (US)
Pages (from-to)	1389-1401
Number of pages	13
Journal	Child development
Volume	90
Issue number	4
DOIs	https://doi.org/10.1111/cdev.13154
State	Published - Jul 1 2019

ASJC Scopus subject areas

Education
Developmental and Educational Psychology
Pediatrics, Perinatology, and Child Health

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10.1111/cdev.13154

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Hanson, J. L., Gillmore, A. D., Yu, T., Holmes, C. J., Hallowell, E. S., Barton, A. W., Beach, S. R. H., Galván, A., MacKillop, J., Windle, M., Chen, E., Miller, G. E., Sweet, L. H., & Brody, G. H. (2019). A Family Focused Intervention Influences Hippocampal-Prefrontal Connectivity Through Gains in Self-Regulation. Child development, 90(4), 1389-1401. https://doi.org/10.1111/cdev.13154

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abstract = "The stressors associated with poverty increase the risks for externalizing psychopathology; however, specific patterns of neurobiology and higher self-regulation may buffer against these effects. This study leveraged a randomized control trial, aimed at increasing self-regulation at ~11 years of age. As adults, these same individuals completed functional MRI scanning (Mage = 24.88 years; intervention n = 44; control n = 49). Functional connectivity between the hippocampus and ventromedial prefrontal cortex was examined in relation to the intervention, gains in self-regulation, and present-day externalizing symptoms. Increased connectivity between these brain areas was noted in the intervention group compared to controls. Furthermore, individual gains in self-regulation, instilled by the intervention, statistically explained this brain difference. These results begin to connect neurobiological and psychosocial markers of risk and resiliency.",

author = "Hanson, {Jamie L.} and Gillmore, {Alysha D.} and Tianyi Yu and Holmes, {Christopher J.} and Hallowell, {Emily S.} and Barton, {Allen W.} and Beach, {Steven R.H.} and Adrianna Galv{\'a}n and James MacKillop and Michael Windle and Edith Chen and Miller, {Gregory E.} and Sweet, {Lawrence H.} and Brody, {Gene H.}",

note = "Funding Information: We thank all the staff at the Center for Translational & Prevention Science and The Center for Family Research, both at The University of Georgia, Athens, for their assistance with data collection and study management. This work was supported by National Institute on Drug Abuse Grants P30-DA027827 (to Gene H. Brody). Publisher Copyright: {\textcopyright} 2018 The Authors. Child Development published by Wiley Periodicals, Inc. on behalf of Society for Research in Child Development.",

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AU - Sweet, Lawrence H.

AU - Brody, Gene H.

N1 - Funding Information: We thank all the staff at the Center for Translational & Prevention Science and The Center for Family Research, both at The University of Georgia, Athens, for their assistance with data collection and study management. This work was supported by National Institute on Drug Abuse Grants P30-DA027827 (to Gene H. Brody). Publisher Copyright: © 2018 The Authors. Child Development published by Wiley Periodicals, Inc. on behalf of Society for Research in Child Development.

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N2 - The stressors associated with poverty increase the risks for externalizing psychopathology; however, specific patterns of neurobiology and higher self-regulation may buffer against these effects. This study leveraged a randomized control trial, aimed at increasing self-regulation at ~11 years of age. As adults, these same individuals completed functional MRI scanning (Mage = 24.88 years; intervention n = 44; control n = 49). Functional connectivity between the hippocampus and ventromedial prefrontal cortex was examined in relation to the intervention, gains in self-regulation, and present-day externalizing symptoms. Increased connectivity between these brain areas was noted in the intervention group compared to controls. Furthermore, individual gains in self-regulation, instilled by the intervention, statistically explained this brain difference. These results begin to connect neurobiological and psychosocial markers of risk and resiliency.

AB - The stressors associated with poverty increase the risks for externalizing psychopathology; however, specific patterns of neurobiology and higher self-regulation may buffer against these effects. This study leveraged a randomized control trial, aimed at increasing self-regulation at ~11 years of age. As adults, these same individuals completed functional MRI scanning (Mage = 24.88 years; intervention n = 44; control n = 49). Functional connectivity between the hippocampus and ventromedial prefrontal cortex was examined in relation to the intervention, gains in self-regulation, and present-day externalizing symptoms. Increased connectivity between these brain areas was noted in the intervention group compared to controls. Furthermore, individual gains in self-regulation, instilled by the intervention, statistically explained this brain difference. These results begin to connect neurobiological and psychosocial markers of risk and resiliency.

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A Family Focused Intervention Influences Hippocampal-Prefrontal Connectivity Through Gains in Self-Regulation

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