A fast rod photoreceptor signaling pathway in the mammalian retina

Wei Li; Shan Chen; Steven H. Devries

doi:10.1038/nn.2507

A fast rod photoreceptor signaling pathway in the mammalian retina

Wei Li, Shan Chen, Steven H. Devries

Ophthalmology

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Rod photoreceptors were recently shown to contact 'Off' cone bipolar cells, providing an alternative pathway for rod signal flow in the mammalian retina. By recording from pairs of rods and Off cone bipolar cells in the ground squirrel (Spermophilus tridecemlineatus), we measured the synaptic responses of mammalian rods unfiltered by the slow kinetics of the rod bipolar cell response. We show that vesicle fusion and turnover in mammalian rods is fast, and that this new pathway can mediate rapid signaling.

Original language	English (US)
Pages (from-to)	414-416
Number of pages	3
Journal	Nature neuroscience
Volume	13
Issue number	4
DOIs	https://doi.org/10.1038/nn.2507
State	Published - Apr 2010

ASJC Scopus subject areas

Neuroscience(all)

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10.1038/nn.2507

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title = "A fast rod photoreceptor signaling pathway in the mammalian retina",

abstract = "Rod photoreceptors were recently shown to contact 'Off' cone bipolar cells, providing an alternative pathway for rod signal flow in the mammalian retina. By recording from pairs of rods and Off cone bipolar cells in the ground squirrel (Spermophilus tridecemlineatus), we measured the synaptic responses of mammalian rods unfiltered by the slow kinetics of the rod bipolar cell response. We show that vesicle fusion and turnover in mammalian rods is fast, and that this new pathway can mediate rapid signaling.",

author = "Wei Li and Shan Chen and Devries, {Steven H.}",

note = "Funding Information: This work was supported by National Institutes of Health grants (R01EY12141) to S.H.D. and (F32EY017257) to W.L., the National Eye Institute Intramural Research Program to W.L. and S.C., and Research to Prevent Blindness.",

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AB - Rod photoreceptors were recently shown to contact 'Off' cone bipolar cells, providing an alternative pathway for rod signal flow in the mammalian retina. By recording from pairs of rods and Off cone bipolar cells in the ground squirrel (Spermophilus tridecemlineatus), we measured the synaptic responses of mammalian rods unfiltered by the slow kinetics of the rod bipolar cell response. We show that vesicle fusion and turnover in mammalian rods is fast, and that this new pathway can mediate rapid signaling.

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A fast rod photoreceptor signaling pathway in the mammalian retina

Abstract

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