A fiber optic-based system for behavioral eyeblink measurement in a MRI environment

Michael J. Miller, Limin Li, Craig Weiss, John F. Disterhoft, Alice M. Wyrwicz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

We previously described a reliable system to control the timing of multiple stimuli and to detect behavioral eyeblink responses in fMRI studies of learning in animals. Here, we report a significant advancement of the original system, which incorporates a fiber-optic probe in order to avoid the interference associated with the application of pulsed field gradients during MR imaging, particularly echo planar imaging. Eyeblink responses recorded with our fiber-optic probe and modified detection circuit demonstrate the ability of our new system to acquire behavioral data free of gradient-induced artifacts, thereby eliminating the need for low-pass filtering. This fiber optic-based system should be applicable to both animal and human imaging experiments.

Original languageEnglish (US)
Pages (from-to)83-87
Number of pages5
JournalJournal of Neuroscience Methods
Volume141
Issue number1
DOIs
StatePublished - Jan 30 2005

Keywords

  • Eyeblink conditioning
  • Fiber optic
  • Infrared reflectance
  • fMRI

ASJC Scopus subject areas

  • Neuroscience(all)

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