A fiber optic probe design to measure depth-limited optical properties IN-VIVO with Low-coherence Enhanced Backscattering (LEBS) Spectroscopy

Nikhil N. Mutyal*, Andrew Radosevich, Bradley Gould, Jeremy D. Rogers, Andrew Gomes, Vladimir Turzhitsky, Vadim Backman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Low-coherence enhanced backscattering (LEBS) spectroscopy is an angular resolved backscattering technique that is sensitive to subdiffusion light transport length scales in which information about scattering phase function is preserved. Our group has shown the ability to measure the spatial backscattering impulse response function along with depth-selective optical properties in tissue ex-vivo using LEBS. Here we report the design and implementation of a lens-free fiber optic LEBS probe capable of providing depth-limited measurements of the reduced scattering coefficient in-vivo. Experimental measurements combined with Monte Carlo simulation of scattering phantoms consisting of polystyrene microspheres in water are used to validate the performance of the probe. Additionally, depth-limited capabilities are demonstrated using Monte Carlo modeling and experimental measurements from a two-layered phantom.

Original languageEnglish (US)
Pages (from-to)19643-19657
Number of pages15
JournalOptics Express
Volume20
Issue number18
DOIs
StatePublished - Aug 27 2012

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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