TY - JOUR
T1 - A fixed-dose combination of adapalene 0.1%BPO 2.5% allows an early and sustained improvement in quality of life and patient treatment satisfaction in severe acne
AU - Brodell, Robert T.
AU - Schlosser, Bethanee J.
AU - Rafal, Elyse
AU - Toth, Darryl
AU - Tyring, Stephen
AU - Wertheimer, Albert
AU - Kerrouche, Nabil
AU - Bucher, Delphine
PY - 2012/2/1
Y1 - 2012/2/1
N2 - Introduction: Acne has a significant negative impact on quality of life (QoL): lack of self-confidence, depressive symptoms and suicidal thoughts. The objective was to assess the impact of an initial and continued therapy in severe acne patients through patient-related outcomes (PRO). Methods: In two sequential double-blind randomized studies, patients received either adapalene 0.1% and benzoyl peroxide 2.5% (ABPO) or vehicle, associated with doxycycline 100 mg for 12 weeks. Patients having obtained at least a good improvement according to investigator global assessment were re-randomized for a 24-week therapy with ABPO or vehicle. PROs were assessed using the Acne-QoL and a patient treatment satisfaction questionnaire. Results: QoL was improved at week 12 in all domains with a significant difference for the Acne-symptoms domain (p < 0.001) in favor of the ABPO regimen. Additional 24-week ABPO treatment showed a sustained improvement, significant (p < 0.001) for all domains except for Acne-symptoms. In the vehicle arm, QoL significantly worsened for all domains (p < 0.03). At weeks 12 and 36, a significantly higher proportion of patients receiving ABPO vs. vehicle reported high satisfaction for five out of six treatment satisfaction items. Conclusions: The early and sustained improvement of these PROs is correlated to the fast onset of action of ABPO, the treatment effectiveness and a good safety profile.
AB - Introduction: Acne has a significant negative impact on quality of life (QoL): lack of self-confidence, depressive symptoms and suicidal thoughts. The objective was to assess the impact of an initial and continued therapy in severe acne patients through patient-related outcomes (PRO). Methods: In two sequential double-blind randomized studies, patients received either adapalene 0.1% and benzoyl peroxide 2.5% (ABPO) or vehicle, associated with doxycycline 100 mg for 12 weeks. Patients having obtained at least a good improvement according to investigator global assessment were re-randomized for a 24-week therapy with ABPO or vehicle. PROs were assessed using the Acne-QoL and a patient treatment satisfaction questionnaire. Results: QoL was improved at week 12 in all domains with a significant difference for the Acne-symptoms domain (p < 0.001) in favor of the ABPO regimen. Additional 24-week ABPO treatment showed a sustained improvement, significant (p < 0.001) for all domains except for Acne-symptoms. In the vehicle arm, QoL significantly worsened for all domains (p < 0.03). At weeks 12 and 36, a significantly higher proportion of patients receiving ABPO vs. vehicle reported high satisfaction for five out of six treatment satisfaction items. Conclusions: The early and sustained improvement of these PROs is correlated to the fast onset of action of ABPO, the treatment effectiveness and a good safety profile.
KW - Acne-QoL
KW - Patient satisfaction questionnaire
KW - Patient-related outcomes
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U2 - 10.3109/09546634.2011.643221
DO - 10.3109/09546634.2011.643221
M3 - Article
C2 - 22103674
AN - SCOPUS:84856015497
VL - 23
SP - 26
EP - 34
JO - Journal of Dermatological Treatment
JF - Journal of Dermatological Treatment
SN - 0954-6634
IS - 1
ER -