Doubly censored data often arise in medical studies of disease progression involving two related events for which both an originating and a terminating event are interval-censored. Although regression modeling for such doubly censored data may be complicated, we propose a simple semiparametric regression modeling strategy based on jackknife pseudo-observations obtained using nonparametric estimators of the survival function. Inference is carried out via generalized estimating equations. Simulations studies show that the proposed method produces virtually unbiased covariate effect estimates, even for moderate sample sizes. A prostate cancer study example illustrates the practical advantages of the proposed approach.
- doubly censored data
- survival analysis
ASJC Scopus subject areas
- Statistics and Probability
- Health Information Management