A Focused Look at Obesity and the Preimplantation Trophoblast

Darcy E. Broughton, Emily S. Jungheim*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Obesity is associated with a myriad of adverse reproductive outcomes including miscarriage, fetal growth abnormalities, and preeclampsia. While the mechanisms involved are likely multifactorial, the potential impact of obesity on the preimplantation embryonic trophoblast cannot be overlooked - particularly given the role the trophoblast plays in endometrial invasion and implantation. Appropriate trophoblast function is critical in establishing a normal pregnancy. Insufficient or impaired trophoblast invasion is associated with early miscarriage, fetal growth abnormalities, and preeclampsia. Thus, any negative impact obesity may impose on the trophoblast may represent a root cause for several adverse reproductive outcomes seen more commonly among obese women. While little is known about obesity's specific impact on the human trophoblast, in vitro studies and animal models provide insight. In this article, we review what is known on this topic and provide a basis for future work, investigating therapeutic targets for improved reproductive outcomes in the setting of maternal obesity.

Original languageEnglish (US)
Pages (from-to)5-10
Number of pages6
JournalSeminars in reproductive medicine
Volume34
Issue number1
DOIs
StatePublished - Dec 22 2015
Externally publishedYes

Keywords

  • endometrium
  • implantation
  • obesity
  • trophoblast

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Endocrinology
  • Obstetrics and Gynecology
  • Physiology (medical)

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