A fungal multicopper oxidase restores iron homeostasis in aceruloplasminemia

Z. Leah Harris, Sandra R. Davis-Kaplan, Jonathan D. Gitlin, Jerry Kaplan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Mutations that lead to a loss of the copper-containing plasma enzyme ceruloplasmin disrupt mammalian iron homeostasis. The mechanism by which ceruloplasmin mobilizes iron from cell stores has been controversial. We demonstrate that injection of a soluble copper-containing yeast protein Fet3p can restore iron homeostasis in phlebotomized mice with a deletion of the ceruloplasmin gene. These results show the conservation of function of copper-containing proteins in eukaryotic iron metabolism.

Original languageEnglish (US)
Pages (from-to)4672-4673
Number of pages2
JournalBlood
Volume103
Issue number12
DOIs
StatePublished - Jun 15 2004

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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