A fungal multicopper oxidase restores iron homeostasis in aceruloplasminemia

Z. Leah Harris; Sandra R. Davis-Kaplan; Jonathan D. Gitlin; Jerry Kaplan

doi:10.1182/blood-2003-11-4060

A fungal multicopper oxidase restores iron homeostasis in aceruloplasminemia

Z. Leah Harris, Sandra R. Davis-Kaplan, Jonathan D. Gitlin, Jerry Kaplan^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Mutations that lead to a loss of the copper-containing plasma enzyme ceruloplasmin disrupt mammalian iron homeostasis. The mechanism by which ceruloplasmin mobilizes iron from cell stores has been controversial. We demonstrate that injection of a soluble copper-containing yeast protein Fet3p can restore iron homeostasis in phlebotomized mice with a deletion of the ceruloplasmin gene. These results show the conservation of function of copper-containing proteins in eukaryotic iron metabolism.

Original language	English (US)
Pages (from-to)	4672-4673
Number of pages	2
Journal	Blood
Volume	103
Issue number	12
DOIs	https://doi.org/10.1182/blood-2003-11-4060
State	Published - Jun 15 2004

Funding

ASJC Scopus subject areas

Hematology
Biochemistry
Cell Biology
Immunology

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10.1182/blood-2003-11-4060

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abstract = "Mutations that lead to a loss of the copper-containing plasma enzyme ceruloplasmin disrupt mammalian iron homeostasis. The mechanism by which ceruloplasmin mobilizes iron from cell stores has been controversial. We demonstrate that injection of a soluble copper-containing yeast protein Fet3p can restore iron homeostasis in phlebotomized mice with a deletion of the ceruloplasmin gene. These results show the conservation of function of copper-containing proteins in eukaryotic iron metabolism.",

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AU - Harris, Z. Leah

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AU - Gitlin, Jonathan D.

AU - Kaplan, Jerry

PY - 2004/6/15

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N2 - Mutations that lead to a loss of the copper-containing plasma enzyme ceruloplasmin disrupt mammalian iron homeostasis. The mechanism by which ceruloplasmin mobilizes iron from cell stores has been controversial. We demonstrate that injection of a soluble copper-containing yeast protein Fet3p can restore iron homeostasis in phlebotomized mice with a deletion of the ceruloplasmin gene. These results show the conservation of function of copper-containing proteins in eukaryotic iron metabolism.

AB - Mutations that lead to a loss of the copper-containing plasma enzyme ceruloplasmin disrupt mammalian iron homeostasis. The mechanism by which ceruloplasmin mobilizes iron from cell stores has been controversial. We demonstrate that injection of a soluble copper-containing yeast protein Fet3p can restore iron homeostasis in phlebotomized mice with a deletion of the ceruloplasmin gene. These results show the conservation of function of copper-containing proteins in eukaryotic iron metabolism.

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A fungal multicopper oxidase restores iron homeostasis in aceruloplasminemia

Abstract

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ASJC Scopus subject areas

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