Abstract
Solutions at high salt concentrations are used to crystallize or segregate charged colloids, including proteins and polyelectrolytes via a complex mechanism referred to as “salting-out.” This chapter combines small-angle X-ray scattering, molecular dynamics simulations, and liquid-state theory to show that salting-out is a long-range interaction, which is controlled by electrolyte concentration and colloid charge density. As a model system, it analyzes gold nanoparticles coated with noncomplementary DNA designed to prevent interparticle assembly via Watson-Crick hybridization. The chapter shows that electrolyte-mediated long-range interparticle attractions are possible in bulk solutions in the regime of high ionic strength. It provides evidence that by molecular dynamics simulations and liquid-state theory, the ionic correlations in the concentrated electrolyte induce interparticle long-range attractions and drive the assembly of charged nanoparticles.
Original language | English (US) |
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Title of host publication | Spherical Nucleic Acids |
Subtitle of host publication | Volume 2 |
Publisher | Jenny Stanford Publishing |
Pages | 587-600 |
Number of pages | 14 |
Volume | 2 |
ISBN (Electronic) | 9781000092363 |
ISBN (Print) | 9789814877220 |
DOIs | |
State | Published - Jan 1 2021 |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology
- General Engineering
- General Chemistry