A General Approach to DNA-Programmable Atom Equivalents

Chuan Zhang, Robert J. Macfarlane, Kaylie L. Young, Chung Hang J. Choi, Liangliang Hao, Evelyn Auyeung, Guoliang Liu, Xiaozhu Zhou, Chad A. Mirkin*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Solutions at high salt concentrations are used to crystallize or segregate charged colloids, including proteins and polyelectrolytes via a complex mechanism referred to as “salting-out.” This chapter combines small-angle X-ray scattering, molecular dynamics simulations, and liquid-state theory to show that salting-out is a long-range interaction, which is controlled by electrolyte concentration and colloid charge density. As a model system, it analyzes gold nanoparticles coated with noncomplementary DNA designed to prevent interparticle assembly via Watson-Crick hybridization. The chapter shows that electrolyte-mediated long-range interparticle attractions are possible in bulk solutions in the regime of high ionic strength. It provides evidence that by molecular dynamics simulations and liquid-state theory, the ionic correlations in the concentrated electrolyte induce interparticle long-range attractions and drive the assembly of charged nanoparticles.

Original languageEnglish (US)
Title of host publicationSpherical Nucleic Acids
Subtitle of host publicationVolume 2
PublisherJenny Stanford Publishing
Pages587-600
Number of pages14
Volume2
ISBN (Electronic)9781000092363
ISBN (Print)9789814877220
DOIs
StatePublished - Jan 1 2021

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Engineering
  • General Chemistry

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