A general multistage procedure for k-out-of-n gatekeeping

Dong Xi*, Ajit C. Tamhane

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

We generalize a multistage procedure for parallel gatekeeping to what we refer to as k-out-of-n gatekeeping in which at least k out of n hypotheses ( 1 ≤ k ≤ n) in a gatekeeper family must be rejected in order to test the hypotheses in the following family. This gatekeeping restriction arises in certain types of clinical trials; for example, in rheumatoid arthritis trials, it is required that efficacy be shown on at least three of the four primary endpoints. We provide a unified theory of multistage procedures for arbitrary k, with k=1 corresponding to parallel gatekeeping and k=n to serial gatekeeping. The theory provides an insight into the construction of truncated separable multistage procedures using the closure method. Explicit formulae for calculating the adjusted p-values are given. The proposed procedure is simpler to apply for this particular problem using a stepwise algorithm than the mixture procedure and the graphical procedure with memory using entangled graphs.

Original languageEnglish (US)
Pages (from-to)1321-1335
Number of pages15
JournalStatistics in Medicine
Volume33
Issue number8
DOIs
StatePublished - Apr 15 2014

Keywords

  • Closed procedure
  • Error rate function
  • Familywise error rate
  • Hochberg procedure
  • Holm procedure
  • Hommel procedure
  • Separable procedures
  • Truncated procedures

ASJC Scopus subject areas

  • Epidemiology
  • Statistics and Probability

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