A Genetic Linkage Map with 29 Loci Spanning Human Chromosome 13q

Steven Gerken; Mark Leppert; Peter O'Connell; Webster Cavenee; C. David James; Linda Ballard; Dora Stauffer; Tami Elsner; Rosemarie Plaetke; Jean Marc Lalouel; Ray White

doi:10.1006/geno.1993.1219

A Genetic Linkage Map with 29 Loci Spanning Human Chromosome 13q

Steven Gerken^*, Mark Leppert, Peter O'Connell, Webster Cavenee, C. David James, Linda Ballard, Dora Stauffer, Tami Elsner, Rosemarie Plaetke, Jean Marc Lalouel, Ray White

^*Corresponding author for this work

Neurological Surgery

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A genetic linkage map for the long arm of human chromosome 13 contains 29 loci derived from 38 probe and enzyme combinations and two protein polymorphisms. Thirteen loci form a continuous linkage map of 106 cM in males and 230 cM in females; each was placed on the map with support of at least 1000:1 against alternative orders. On a sex-combined basis, the mean distance between markers is less than 13 cM. The order of loci on the genetic map agrees with physical localization data that show that together these 13 loci cover 13q13 to 13q34. This map was used to regionally localize the 16 remaining loci. The linkage maps reported here should prove to be useful to investigators mapping disease genes and other genetic markers on human chromosome 13.

Original language	English (US)
Pages (from-to)	515-519
Number of pages	5
Journal	Genomics
Volume	16
Issue number	2
DOIs	https://doi.org/10.1006/geno.1993.1219
State	Published - May 1993

ASJC Scopus subject areas

Genetics

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10.1006/geno.1993.1219

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title = "A Genetic Linkage Map with 29 Loci Spanning Human Chromosome 13q",

abstract = "A genetic linkage map for the long arm of human chromosome 13 contains 29 loci derived from 38 probe and enzyme combinations and two protein polymorphisms. Thirteen loci form a continuous linkage map of 106 cM in males and 230 cM in females; each was placed on the map with support of at least 1000:1 against alternative orders. On a sex-combined basis, the mean distance between markers is less than 13 cM. The order of loci on the genetic map agrees with physical localization data that show that together these 13 loci cover 13q13 to 13q34. This map was used to regionally localize the 16 remaining loci. The linkage maps reported here should prove to be useful to investigators mapping disease genes and other genetic markers on human chromosome 13.",

author = "Steven Gerken and Mark Leppert and Peter O'Connell and Webster Cavenee and James, {C. David} and Linda Ballard and Dora Stauffer and Tami Elsner and Rosemarie Plaetke and Lalouel, {Jean Marc} and Ray White",

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T1 - A Genetic Linkage Map with 29 Loci Spanning Human Chromosome 13q

AU - Gerken, Steven

AU - Leppert, Mark

AU - O'Connell, Peter

AU - Cavenee, Webster

AU - James, C. David

AU - Ballard, Linda

AU - Stauffer, Dora

AU - Elsner, Tami

AU - Plaetke, Rosemarie

AU - Lalouel, Jean Marc

AU - White, Ray

PY - 1993/5

Y1 - 1993/5

N2 - A genetic linkage map for the long arm of human chromosome 13 contains 29 loci derived from 38 probe and enzyme combinations and two protein polymorphisms. Thirteen loci form a continuous linkage map of 106 cM in males and 230 cM in females; each was placed on the map with support of at least 1000:1 against alternative orders. On a sex-combined basis, the mean distance between markers is less than 13 cM. The order of loci on the genetic map agrees with physical localization data that show that together these 13 loci cover 13q13 to 13q34. This map was used to regionally localize the 16 remaining loci. The linkage maps reported here should prove to be useful to investigators mapping disease genes and other genetic markers on human chromosome 13.

AB - A genetic linkage map for the long arm of human chromosome 13 contains 29 loci derived from 38 probe and enzyme combinations and two protein polymorphisms. Thirteen loci form a continuous linkage map of 106 cM in males and 230 cM in females; each was placed on the map with support of at least 1000:1 against alternative orders. On a sex-combined basis, the mean distance between markers is less than 13 cM. The order of loci on the genetic map agrees with physical localization data that show that together these 13 loci cover 13q13 to 13q34. This map was used to regionally localize the 16 remaining loci. The linkage maps reported here should prove to be useful to investigators mapping disease genes and other genetic markers on human chromosome 13.

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A Genetic Linkage Map with 29 Loci Spanning Human Chromosome 13q

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