A Genetic Linkage Map with 29 Loci Spanning Human Chromosome 13q

Steven Gerken*, Mark Leppert, Peter O'Connell, Webster Cavenee, C. David James, Linda Ballard, Dora Stauffer, Tami Elsner, Rosemarie Plaetke, Jean Marc Lalouel, Ray White

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

A genetic linkage map for the long arm of human chromosome 13 contains 29 loci derived from 38 probe and enzyme combinations and two protein polymorphisms. Thirteen loci form a continuous linkage map of 106 cM in males and 230 cM in females; each was placed on the map with support of at least 1000:1 against alternative orders. On a sex-combined basis, the mean distance between markers is less than 13 cM. The order of loci on the genetic map agrees with physical localization data that show that together these 13 loci cover 13q13 to 13q34. This map was used to regionally localize the 16 remaining loci. The linkage maps reported here should prove to be useful to investigators mapping disease genes and other genetic markers on human chromosome 13.

Original languageEnglish (US)
Pages (from-to)515-519
Number of pages5
JournalGenomics
Volume16
Issue number2
DOIs
StatePublished - May 1993

ASJC Scopus subject areas

  • Genetics

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