A genetic mouse model of adult-onset, pervasive central nervous system demyelination with robust remyelination

Maria Traka, Kavin Arasi, Robin L. Avila, Joseph R. Podojil, Athena Christakos, Stephen D. Miller, Betty Soliven, Brian Popko*

*Corresponding author for this work

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

Adult-onset demyelinating disorders of the central nervous system represent the most common neurological abnormalities in young adults. Nevertheless, our understanding of disease pathogenesis and recovery in demyelinating disorders remains incomplete. To facilitate investigation into these processes, we have developed a new mouse model system that allows for the induction of dipththeria toxin A subunit expression in adult oligodendrocytes, resulting in widespread oligodendrocyte loss and demyelination of the central nervous system. These mice develop severe ataxia and tremor that correlates with impaired axonal conduction in the spinal cord. Strikingly, these animals fully recover from their motor and physiological defects and display extensive oligodendrocyte replenishment and widespread remyelination. This model system demonstrates the robust reparative potential of myelin in the central nervous system and provides a promising model for the quantitative assessment of therapeutic interventions that promote remyelination.

Original languageEnglish (US)
Pages (from-to)3017-3029
Number of pages13
JournalBrain
Volume133
Issue number10
DOIs
StatePublished - Oct 2010

Keywords

  • demyelination
  • multiple sclerosis
  • myelin
  • oligodendrocyte
  • remyelination

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'A genetic mouse model of adult-onset, pervasive central nervous system demyelination with robust remyelination'. Together they form a unique fingerprint.

Cite this