A genome-wide screen for hyposmia susceptibility loci

Jayant M. Pinto*, Sanguansak Thanaviratananich, M. Geoffrey Hayes, Robert M. Naclerio, Carole Ober

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Olfactory dysfunction is an important public health problem in the United States, with approximately 14 million elderly Americans having chronic olfactory impairment. We performed a genome-wide linkage scan for loci influencing susceptibility to hyposmia in the Hutterites, a founder population of European ancestry. Using interviews regarding the olfactory medical history and psychophysical smell testing, we identified 25 individuals with severe hyposmia. Elimination of subjects with confounding conditions yielded 7 hyposmics for analysis. A 52-member pedigree including all affected individuals was constructed from the larger, >1623-member pedigree, and a genome-wide screen for loci influencing the trait of hyposmia using 1123 markers was performed. The most significant evidence for linkage with hyposmia extended over a 45 cM region on chromosome 4q (P = 0.0013). Although this signal meets the criteria for suggestive linkage only and will require replication, these results offer the strongest data to date on the effects of genetic variation on olfactory dysfunction.

Original languageEnglish (US)
Pages (from-to)319-329
Number of pages11
JournalChemical Senses
Volume33
Issue number4
DOIs
StatePublished - Apr 2008

Keywords

  • Eenome
  • Hyposmia
  • Linkage
  • Olfaction

ASJC Scopus subject areas

  • Physiology
  • Sensory Systems
  • Physiology (medical)
  • Behavioral Neuroscience

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