A glycoprotein isolated from the sponge, Pachymatisma johnstonii, has anti-leishmanial activity

Patrice Le Pape*, Mohamed Zidane, Hiam Abdala, Marie Thérèse Moré

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

A high anti-leishmanial activity was observed in an aqueous extract from the marine sponge Pachymatisma johnstonii, Bowerbank 1842 (Demospongiae, Geodiidae). Pachymatismin, a glycoprotein, was purified and shown to be a cytotoxic agent, which acts on promastigote and clinical-like amastigote stages with IC50 about 1 μg protein/ml and induces changes in the cell shape, phospholipase A2 activity and invasion capacity of the parasite. We believe pachymatismin is the first reported substance from a marine organism with anti-leishmanial activity. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)51-56
Number of pages6
JournalCell Biology International
Volume24
Issue number1
DOIs
StatePublished - Jan 1 2000

Keywords

  • Anti-Leishmania
  • Glycoprotein
  • Marine sponge
  • Pachymatismin
  • Parasite

ASJC Scopus subject areas

  • Cell Biology

Fingerprint Dive into the research topics of 'A glycoprotein isolated from the sponge, Pachymatisma johnstonii, has anti-leishmanial activity'. Together they form a unique fingerprint.

Cite this