A glycoprotein isolated from the sponge, Pachymatisma johnstonii, has anti-leishmanial activity

Patrice Le Pape; Mohamed Zidane; Hiam Abdala; Marie Thérèse Moré

doi:10.1006/cbir.1999.0450

A glycoprotein isolated from the sponge, Pachymatisma johnstonii, has anti-leishmanial activity

Patrice Le Pape^*, Mohamed Zidane, Hiam Abdala, Marie Thérèse Moré

^*Corresponding author for this work

Medicine, Pulmonary Division

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

A high anti-leishmanial activity was observed in an aqueous extract from the marine sponge Pachymatisma johnstonii, Bowerbank 1842 (Demospongiae, Geodiidae). Pachymatismin, a glycoprotein, was purified and shown to be a cytotoxic agent, which acts on promastigote and clinical-like amastigote stages with IC₅₀ about 1 μg protein/ml and induces changes in the cell shape, phospholipase A₂ activity and invasion capacity of the parasite. We believe pachymatismin is the first reported substance from a marine organism with anti-leishmanial activity. (C) 2000 Academic Press.

Original language	English (US)
Pages (from-to)	51-56
Number of pages	6
Journal	Cell Biology International
Volume	24
Issue number	1
DOIs	https://doi.org/10.1006/cbir.1999.0450
State	Published - Jan 2000

Keywords

Anti-Leishmania
Glycoprotein
Marine sponge
Pachymatismin
Parasite

ASJC Scopus subject areas

Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1006/cbir.1999.0450

Cite this

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title = "A glycoprotein isolated from the sponge, Pachymatisma johnstonii, has anti-leishmanial activity",

abstract = "A high anti-leishmanial activity was observed in an aqueous extract from the marine sponge Pachymatisma johnstonii, Bowerbank 1842 (Demospongiae, Geodiidae). Pachymatismin, a glycoprotein, was purified and shown to be a cytotoxic agent, which acts on promastigote and clinical-like amastigote stages with IC50 about 1 μg protein/ml and induces changes in the cell shape, phospholipase A2 activity and invasion capacity of the parasite. We believe pachymatismin is the first reported substance from a marine organism with anti-leishmanial activity. (C) 2000 Academic Press.",

keywords = "Anti-Leishmania, Glycoprotein, Marine sponge, Pachymatismin, Parasite",

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AU - Le Pape, Patrice

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AU - Abdala, Hiam

AU - Moré, Marie Thérèse

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AB - A high anti-leishmanial activity was observed in an aqueous extract from the marine sponge Pachymatisma johnstonii, Bowerbank 1842 (Demospongiae, Geodiidae). Pachymatismin, a glycoprotein, was purified and shown to be a cytotoxic agent, which acts on promastigote and clinical-like amastigote stages with IC50 about 1 μg protein/ml and induces changes in the cell shape, phospholipase A2 activity and invasion capacity of the parasite. We believe pachymatismin is the first reported substance from a marine organism with anti-leishmanial activity. (C) 2000 Academic Press.

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KW - Glycoprotein

KW - Marine sponge

KW - Pachymatismin

KW - Parasite

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A glycoprotein isolated from the sponge, Pachymatisma johnstonii, has anti-leishmanial activity

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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