A Graded Evaluation of Outcomes Following Pancreaticoduodenectomy with Major Vascular Resection in Pancreatic Cancer

Olga Kantor, Mark S. Talamonti, Susan J. Stocker, Chi Hsiung Wang, David J. Winchester, David Jason Bentrem, Richard A. Prinz, Marshall S. Baker*

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Previous studies examining short- and long-term outcomes of pancreaticoduodenectomy with vascular resection for pancreatic adenocarcinoma have not graded perioperative complication severity. These studies may provide incomplete assessments of the efficacy of vascular resection. In the current study, we evaluated 36 patients who had pancreaticoduodenectomy with major vascular resection. These were matched 1:3 by tumor stage and age to patients who had pancreaticoduodenectomy without vascular resection. Charts were reviewed to identify all complications and 90-day readmissions. Complications were graded as either severe or minor adverse postoperative outcomes, taking into account the total length of stay. There were no statistical differences in patient demographics, comorbidities, or symptoms between the groups. Patients who had vascular resection had significantly increased rates of severe adverse postoperative outcomes, readmissions, lengths of hospital stay, as well as higher hospital costs. Hypoalbuminemia and major vascular resection were independent predictors of severe adverse postoperative outcomes. On multivariate Cox-regression survival analysis, patients who had vascular resection had decreased recurrence-free (12 vs. 17 months) and overall (17 vs. 29 months) survival. Major vascular resection was a predictor of mortality, may be an independent prognostic factor for survival, and may warrant incorporation into future staging systems.

Original languageEnglish (US)
Pages (from-to)284-292
Number of pages9
JournalJournal of Gastrointestinal Surgery
Volume20
Issue number2
DOIs
StatePublished - Feb 1 2016

    Fingerprint

Keywords

  • Pancreatic adenocarcinoma
  • Pancreaticoduodenectomy
  • Vascular resection

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

Cite this