A gradient of glucocorticoid sensitivity among helper T cell cytokines

Jesus Banuelos, Nicholas Z. Lu*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

23 Scopus citations

Abstract

Helper T (Th) cells secret specific cytokines that promote immune responses whereas glucocorticoids limit the extent of immune responses by inhibiting cytokine secretion and other functions of Th cells. However, glucocorticoid resistance develops in subgroups of patients with Th cell-driven diseases such as asthma and Crohn's disease. Recent evidence supports that Th1, Th2, and Th17 cells have distinct glucocorticoid sensitivity. Th1 cells are sensitive to glucocorticoid-induced apoptosis and cytokine suppression while Th2 cells are sensitive to the latter but not the former and Th17 cells are resistant to both. This gradient of glucocorticoid sensitivity of Th cells corresponds to the glucocorticoid sensitivity of the diseases they underlie. We identify the mechanisms contributing to distinct glucocorticoid sensitivity of Th cells and their cytokines in the literature, as this information is useful to improve treatment strategies for glucocorticoid resistant immunological disorders.

Original languageEnglish (US)
Pages (from-to)27-35
Number of pages9
JournalCytokine and Growth Factor Reviews
Volume31
DOIs
StatePublished - Oct 1 2016

Keywords

  • Glucocorticoid
  • IL-17
  • Th1
  • Th17
  • Th2

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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