A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy

Hyunjae Lee, Tae Kyu Choi, Young Bum Lee, Hye Rim Cho, Roozbeh Ghaffari, Liu Wang, Hyung Jin Choi, Taek Dong Chung, Nanshu Lu, Taeghwan Hyeon, Seung Hong Choi, Dae Hyeong Kim*

*Corresponding author for this work

Research output: Contribution to journalArticle

687 Scopus citations

Abstract

Owing to its high carrier mobility, conductivity, flexibility and optical transparency, graphene is a versatile material in micro- and macroelectronics. However, the low density of electrochemically active defects in graphene synthesized by chemical vapour deposition limits its application in biosensing. Here, we show that graphene doped with gold and combined with a gold mesh has improved electrochemical activity over bare graphene, sufficient to form a wearable patch for sweat-based diabetes monitoring and feedback therapy. The stretchable device features a serpentine bilayer of gold mesh and gold-doped graphene that forms an efficient electrochemical interface for the stable transfer of electrical signals. The patch consists of a heater, temperature, humidity, glucose and pH sensors and polymeric microneedles that can be thermally activated to deliver drugs transcutaneously. We show that the patch can be thermally actuated to deliver Metformin and reduce blood glucose levels in diabetic mice.

Original languageEnglish (US)
Pages (from-to)566-572
Number of pages7
JournalNature nanotechnology
Volume11
Issue number6
DOIs
StatePublished - Jun 1 2016

ASJC Scopus subject areas

  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

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    Lee, H., Choi, T. K., Lee, Y. B., Cho, H. R., Ghaffari, R., Wang, L., Choi, H. J., Chung, T. D., Lu, N., Hyeon, T., Choi, S. H., & Kim, D. H. (2016). A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy. Nature nanotechnology, 11(6), 566-572. https://doi.org/10.1038/nnano.2016.38