A group-mediated, home-based physical activity intervention for patients with peripheral artery disease: Effects on social and psychological function

W. J. Rejeski*, Bonnie Spring, Kathryn Domanchuk, Huimin Tao, Lu Tian, Lihui Zhao, Mary M. McDermott

*Corresponding author for this work

Research output: Contribution to journalArticle

15 Scopus citations


Background: PAD is a disabling, chronic condition of the lower extremities that affects approximately 8 million people in the United States. The purpose of this study was to determine whether an innovative home-based walking exercise program for patients with peripheral artery disease (PAD) improves self-efficacy for walking, desire for physical competence, satisfaction for physical functioning, social functioning, and acceptance of PAD related pain and discomfort.Methods: The design was a 6-month randomized controlled clinical trial of 194 patients with PAD. Participants were randomized to 1 of 2 parallel groups: a home-based group-mediated cognitive behavioral walking intervention or an attention control condition.Results: Of the 194 participants randomized, 178 completed the baseline and 6-month follow-up visit. The mean age was 70.66 (±9.44) and was equally represented by men and women. Close to half of the cohort was African American. Following 6-months of treatment, the intervention group experienced greater improvement on self-efficacy (p = .0008), satisfaction with functioning (p = .0003), pain acceptance (p = .0002), and social functioning (p = .0008) than the control group; the effects were consistent across a number of potential moderating variables. Change in these outcomes was essentially independent of change in 6-minute walk performance.Trial registration: [ClinicalTrials.gov Identifier: NCT00693940].

Original languageEnglish (US)
Article number29
JournalJournal of Translational Medicine
Issue number1
StatePublished - Jan 28 2014



  • Group-mediated intervention
  • Peripheral artery disease
  • Physical activity
  • Psychological function
  • Social function

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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