A gut-to-brain signal of fluid osmolarity controls thirst satiation

Christopher A. Zimmerman, Erica L. Huey, Jamie S. Ahn, Lisa R Beutler, Chan Lek Tan, Seher Kosar, Ling Bai, Yiming Chen, Timothy V. Corpuz, Linda Madisen, Hongkui Zeng, Zachary A. Knight*

*Corresponding author for this work

Research output: Contribution to journalLetter

11 Citations (Scopus)

Abstract

Satiation is the process by which eating and drinking reduce appetite. For thirst, oropharyngeal cues have a critical role in driving satiation by reporting to the brain the volume of fluid that has been ingested 1–12 . By contrast, the mechanisms that relay the osmolarity of ingested fluids remain poorly understood. Here we show that the water and salt content of the gastrointestinal tract are precisely measured and then rapidly communicated to the brain to control drinking behaviour in mice. We demonstrate that this osmosensory signal is necessary and sufficient for satiation during normal drinking, involves the vagus nerve and is transmitted to key forebrain neurons that control thirst and vasopressin secretion. Using microendoscopic imaging, we show that individual neurons compute homeostatic need by integrating this gastrointestinal osmosensory information with oropharyngeal and blood-borne signals. These findings reveal how the fluid homeostasis system monitors the osmolarity of ingested fluids to dynamically control drinking behaviour.

Original languageEnglish (US)
JournalNature
DOIs
StatePublished - Jan 1 2019

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Satiation
Thirst
Osmolar Concentration
Drinking Behavior
Drinking
Brain
Neurons
Vagus Nerve
Appetite
Prosencephalon
Vasopressins
Cues
Gastrointestinal Tract
Homeostasis
Salts
Eating
Water

ASJC Scopus subject areas

  • General

Cite this

Zimmerman, C. A., Huey, E. L., Ahn, J. S., Beutler, L. R., Tan, C. L., Kosar, S., ... Knight, Z. A. (2019). A gut-to-brain signal of fluid osmolarity controls thirst satiation. Nature. https://doi.org/10.1038/s41586-019-1066-x
Zimmerman, Christopher A. ; Huey, Erica L. ; Ahn, Jamie S. ; Beutler, Lisa R ; Tan, Chan Lek ; Kosar, Seher ; Bai, Ling ; Chen, Yiming ; Corpuz, Timothy V. ; Madisen, Linda ; Zeng, Hongkui ; Knight, Zachary A. / A gut-to-brain signal of fluid osmolarity controls thirst satiation. In: Nature. 2019.
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Zimmerman, CA, Huey, EL, Ahn, JS, Beutler, LR, Tan, CL, Kosar, S, Bai, L, Chen, Y, Corpuz, TV, Madisen, L, Zeng, H & Knight, ZA 2019, 'A gut-to-brain signal of fluid osmolarity controls thirst satiation', Nature. https://doi.org/10.1038/s41586-019-1066-x

A gut-to-brain signal of fluid osmolarity controls thirst satiation. / Zimmerman, Christopher A.; Huey, Erica L.; Ahn, Jamie S.; Beutler, Lisa R; Tan, Chan Lek; Kosar, Seher; Bai, Ling; Chen, Yiming; Corpuz, Timothy V.; Madisen, Linda; Zeng, Hongkui; Knight, Zachary A.

In: Nature, 01.01.2019.

Research output: Contribution to journalLetter

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AU - Zimmerman, Christopher A.

AU - Huey, Erica L.

AU - Ahn, Jamie S.

AU - Beutler, Lisa R

AU - Tan, Chan Lek

AU - Kosar, Seher

AU - Bai, Ling

AU - Chen, Yiming

AU - Corpuz, Timothy V.

AU - Madisen, Linda

AU - Zeng, Hongkui

AU - Knight, Zachary A.

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