@article{8f7f7d5a9be0492abed1fafdc9523af5,
title = "A harmonized segmentation protocol for hippocampal and parahippocampal subregions: Why do we need one and what are the key goals?",
abstract = "The advent of high-resolution magnetic resonance imaging (MRI) has enabled in vivo research in a variety of populations and diseases on the structure and function of hippocampal subfields and subdivisions of the parahippocampal gyrus. Because of the many extant and highly discrepant segmentation protocols, comparing results across studies is difficult. To overcome this barrier, the Hippocampal Subfields Group was formed as an international collaboration with the aim of developing a harmonized protocol for manual segmentation of hippocampal and parahippocampal subregions on high-resolution MRI. In this commentary we discuss the goals for this protocol and the associated key challenges involved in its development. These include differences among existing anatomical reference materials, striking the right balance between reliability of measurements and anatomical validity, and the development of a versatile protocol that can be adopted for the study of populations varying in age and health. The commentary outlines these key challenges, as well as the proposed solution of each, with concrete examples from our working plan. Finally, with two examples, we illustrate how the harmonized protocol, once completed, is expected to impact the field by producing measurements that are quantitatively comparable across labs and by facilitating the synthesis of findings across different studies.",
keywords = "MRI, harmonization, hippocampus, parahippocampal gyrus, segmentation",
author = "{for the Hippocampal Subfields Group} and Wisse, {Laura E.M.} and Daugherty, {Ana M.} and Olsen, {Rosanna K.} and David Berron and Carr, {Valerie A.} and Stark, {Craig E.L.} and Amaral, {Robert S.C.} and Katrin Amunts and Augustinack, {Jean C.} and Bender, {Andrew R.} and Bernstein, {Jeffrey D.} and Marina Boccardi and Martina Bocchetta and Alison Burggren and Chakravarty, {M. Mallar} and Marie Chupin and Arne Ekstrom and {de Flores}, Robin and Ricardo Insausti and Prabesh Kanel and Olga Kedo and Kennedy, {Kristen M.} and Kerchner, {Geoffrey A.} and LaRocque, {Karen F.} and Xiuwen Liu and Anne Maass and Nicolai Malykhin and Mueller, {Susanne G.} and Noa Ofen and Palombo, {Daniela J.} and Parekh, {Mansi B.} and Pluta, {John B.} and Pruessner, {Jens C.} and Naftali Raz and Rodrigue, {Karen M.} and Dorothee Schoemaker and Shafer, {Andrea T.} and Steve, {Trevor A.} and Nanthia Suthana and Lei Wang and Winterburn, {Julie L.} and Yassa, {Michael A.} and Yushkevich, {Paul A.} and {la Joie}, Renaud",
note = "Funding Information: The authors thank the members of the larger Hippocampal Subfields Group for their input on the harmonization effort and insightful comments over the years. They acknowledge the work of Ms. Mercedes I{\v n}iguez de Onzo{\v n}o for magnificent technical work. None of the authors has any disclosures, except GAK, who is an employee of Genentech, Inc. See Supplementary Material for a list of collaborators in the Hippocampal Subfields Groups. Publisher Copyright: {\textcopyright} 2016 Wiley Periodicals, Inc.",
year = "2017",
month = jan,
day = "1",
doi = "10.1002/hipo.22671",
language = "English (US)",
volume = "27",
pages = "3--11",
journal = "Hippocampus",
issn = "1050-9631",
publisher = "Wiley-Liss Inc.",
number = "1",
}