A heterophilic adhesion mechanism for platelet/endothelial cell adhesion molecule 1 (cd31)

William A. Muller*, Miriam E. Berman, Peter J. Newman, Horace M. DeLisser, Steven M. Albelda

*Corresponding author for this work

Research output: Contribution to journalArticle

135 Scopus citations

Abstract

The molecular nature of cell adhesion mediated by platelet/endothelial cell adhesion molecule 1 (PECAM-1; CD31) was examined using stably transfected L ceils in a PECAM-dependent aggregation assay. This adhesion was temperature sensitive and divalent cation dependent, with Mg2+ supporting aggregation to a greater degree than Ca2+. PECAM-dependent aggregation was heterophilic: PECAM-1 transfectants bound as readily to control-transfected L cells as to other PECAM-1 transfectants, demonstrating that a molecule endogenously expressed on the L cells serves as the ligand for PECAM in this system and presumably substitutes for the natural human ligand.

Original languageEnglish (US)
Pages (from-to)1401-1404
Number of pages4
JournalJournal of Experimental Medicine
Volume175
Issue number5
DOIs
StatePublished - May 1 1992

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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