A high-density, high-channel count, multiplexed μECOG array for auditory-cortex recordings

Monty A. Escabí, Heather L. Read, Jonathan Viventi, Dae Hyeong Kim, Nathan C. Higgins, Douglas A. Storace, Andrew S K Liu, Adam M. Gifford, John F. Burke, Matthew Campisi, Yun Soung Kim, Andrew E. Avrin, Jan Van der Spiegel, Yonggang Huang, Ming Li, Jian Wu, John A. Rogers, Brian Litt, Yale E. Cohen*

*Corresponding author for this work

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Our understanding of the large-scale population dynamics of neural activity is limited, in part, by our inability to record simultaneously from large regions of the cortex. Here, we validated the use of a large-scale active microelectrode array that simultaneously records 196 multiplexed micro-electrocortigraphical (μECoG) signals from the cortical surface at a very high density (1,600 electrodes/cm2). We compared μECoG measurements in auditory cortex using a custom “active” electrode array to those recorded using a conventional “passive” μECoG array. Both of these array responses were also compared with data recorded via intrinsic optical imaging, which is a standard methodology for recording sound-evoked cortical activity. Custom active μECoG arrays generated more veridical representations of the tonotopic organization of the auditory cortex than current commercially available passive μECoG arrays. Furthermore, the cortical representation could be measured efficiently with the active arrays, requiring as little as 13.5 s of neural data acquisition. Next, we generated spectrotemporal receptive fields from the recorded neural activity on the active μECoG array and identified functional organizational principles comparable to those observed using intrinsic metabolic imaging and single-neuron recordings. This new electrode array technology has the potential for large-scale, temporally precise monitoring and mapping of the cortex, without the use of invasive penetrating electrodes.

Original languageEnglish (US)
Pages (from-to)1566-1583
Number of pages18
JournalJournal of neurophysiology
Volume112
Issue number6
DOIs
StatePublished - Sep 15 2014

Fingerprint

Auditory Cortex
Electrodes
Optical Imaging
Population Dynamics
Microelectrodes
Technology
Neurons

Keywords

  • Auditory cortex
  • Electrocorticography
  • Tonotopy
  • Topography
  • μECoG

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

Cite this

Escabí, M. A., Read, H. L., Viventi, J., Kim, D. H., Higgins, N. C., Storace, D. A., ... Cohen, Y. E. (2014). A high-density, high-channel count, multiplexed μECOG array for auditory-cortex recordings. Journal of neurophysiology, 112(6), 1566-1583. https://doi.org/10.1152/jn.00179.2013
Escabí, Monty A. ; Read, Heather L. ; Viventi, Jonathan ; Kim, Dae Hyeong ; Higgins, Nathan C. ; Storace, Douglas A. ; Liu, Andrew S K ; Gifford, Adam M. ; Burke, John F. ; Campisi, Matthew ; Kim, Yun Soung ; Avrin, Andrew E. ; Van der Spiegel, Jan ; Huang, Yonggang ; Li, Ming ; Wu, Jian ; Rogers, John A. ; Litt, Brian ; Cohen, Yale E. / A high-density, high-channel count, multiplexed μECOG array for auditory-cortex recordings. In: Journal of neurophysiology. 2014 ; Vol. 112, No. 6. pp. 1566-1583.
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Escabí, MA, Read, HL, Viventi, J, Kim, DH, Higgins, NC, Storace, DA, Liu, ASK, Gifford, AM, Burke, JF, Campisi, M, Kim, YS, Avrin, AE, Van der Spiegel, J, Huang, Y, Li, M, Wu, J, Rogers, JA, Litt, B & Cohen, YE 2014, 'A high-density, high-channel count, multiplexed μECOG array for auditory-cortex recordings', Journal of neurophysiology, vol. 112, no. 6, pp. 1566-1583. https://doi.org/10.1152/jn.00179.2013

A high-density, high-channel count, multiplexed μECOG array for auditory-cortex recordings. / Escabí, Monty A.; Read, Heather L.; Viventi, Jonathan; Kim, Dae Hyeong; Higgins, Nathan C.; Storace, Douglas A.; Liu, Andrew S K; Gifford, Adam M.; Burke, John F.; Campisi, Matthew; Kim, Yun Soung; Avrin, Andrew E.; Van der Spiegel, Jan; Huang, Yonggang; Li, Ming; Wu, Jian; Rogers, John A.; Litt, Brian; Cohen, Yale E.

In: Journal of neurophysiology, Vol. 112, No. 6, 15.09.2014, p. 1566-1583.

Research output: Contribution to journalArticle

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AU - Escabí, Monty A.

AU - Read, Heather L.

AU - Viventi, Jonathan

AU - Kim, Dae Hyeong

AU - Higgins, Nathan C.

AU - Storace, Douglas A.

AU - Liu, Andrew S K

AU - Gifford, Adam M.

AU - Burke, John F.

AU - Campisi, Matthew

AU - Kim, Yun Soung

AU - Avrin, Andrew E.

AU - Van der Spiegel, Jan

AU - Huang, Yonggang

AU - Li, Ming

AU - Wu, Jian

AU - Rogers, John A.

AU - Litt, Brian

AU - Cohen, Yale E.

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N2 - Our understanding of the large-scale population dynamics of neural activity is limited, in part, by our inability to record simultaneously from large regions of the cortex. Here, we validated the use of a large-scale active microelectrode array that simultaneously records 196 multiplexed micro-electrocortigraphical (μECoG) signals from the cortical surface at a very high density (1,600 electrodes/cm2). We compared μECoG measurements in auditory cortex using a custom “active” electrode array to those recorded using a conventional “passive” μECoG array. Both of these array responses were also compared with data recorded via intrinsic optical imaging, which is a standard methodology for recording sound-evoked cortical activity. Custom active μECoG arrays generated more veridical representations of the tonotopic organization of the auditory cortex than current commercially available passive μECoG arrays. Furthermore, the cortical representation could be measured efficiently with the active arrays, requiring as little as 13.5 s of neural data acquisition. Next, we generated spectrotemporal receptive fields from the recorded neural activity on the active μECoG array and identified functional organizational principles comparable to those observed using intrinsic metabolic imaging and single-neuron recordings. This new electrode array technology has the potential for large-scale, temporally precise monitoring and mapping of the cortex, without the use of invasive penetrating electrodes.

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Escabí MA, Read HL, Viventi J, Kim DH, Higgins NC, Storace DA et al. A high-density, high-channel count, multiplexed μECOG array for auditory-cortex recordings. Journal of neurophysiology. 2014 Sep 15;112(6):1566-1583. https://doi.org/10.1152/jn.00179.2013