(Chemical Equation Presented) Metal-less Michael: A highly diastereo-and enantioselective intramolecular Michael addition of α,β-unsaturated aldehydes to enones catalyzed by an N-heterocyclic carbene (NHC) has been developed. The reaction is tolerant of alkyl and aromatic substituents, as well as saturated and unsaturated tethers between the enal and conjugate acceptor (see scheme).
|Original language||English (US)|
|Number of pages||4|
|Journal||Angewandte Chemie - International Edition|
|State||Published - 2007|
- Asymmetric catalysis
- Michael addition
- N-heterocyclic carbenes
- Synthetic methods
ASJC Scopus subject areas
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CCDC 631931: Experimental Crystal Structure Determination
Phillips, E. M. (Creator), Wadamoto, M. (Creator), Chan, A. (Creator) & Scheidt, K. A. (Creator), Cambridge Crystallographic Data Centre, 2007
DOI: 10.5517/ccp6kw9, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccp6kw9&sid=DataCite