A Highly Porous Metal-Organic Framework System to Deliver Payloads for Gene Knockdown

Michelle H. Teplensky, Marcus Fantham, Chetan Poudel, Colin Hockings, Meng Lu, Alina Guna, Marta Aragones-Anglada, Peyman Z. Moghadam, Peng Li, Omar K. Farha, Sandra Bernaldo de Quirós Fernández, Frances M. Richards, Duncan I. Jodrell, Gabriele Kaminski Schierle, Clemens F. Kaminski*, David Fairen-Jimenez

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Gene knockdown is an advantageous therapeutic strategy to lower dangerous genetic over-expression. However, the molecules responsible for initiating this process are unstable. Porous nanoparticles called metal-organic frameworks can encapsulate, protect, and deliver these compounds efficaciously without the need for chemical modifications—commonly done to enhance stability. By applying this platform technology, this work demonstrates the successful reduction in expression of a gene by avoiding retention and subsequent degradation in cellular compartments.

Original languageEnglish (US)
Pages (from-to)2926-2941
Number of pages16
JournalChem
Volume5
Issue number11
DOIs
StatePublished - Nov 14 2019

Keywords

  • SDG3: Good health and well-being
  • adsorption
  • cancer
  • drug delivery
  • endosomal escape
  • gene knockdown
  • gene knockdown
  • metal-organic frameworks
  • molecular simulation
  • structured illumination microscopy

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry
  • Environmental Chemistry
  • Chemical Engineering(all)
  • Biochemistry, medical
  • Materials Chemistry

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