A highly sensitive and selective surface-enhanced nanobiosensor

Amanda J. Haes; Richard P. Van Duyne

doi:10.1557/proc-723-o3.1

A highly sensitive and selective surface-enhanced nanobiosensor

Amanda J. Haes^*, Richard P. Van Duyne

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Conference article › peer-review

27 Scopus citations

Abstract

Nanosphere lithography (NSL) derived triangular Ag nanoparticles were used to create an extremely sensitive and specific optical biological and chemical nanosensor. Using simple UV-vis spectroscopy, biotinylated surface-confined Ag nanoparticles were used to detect streptavidin down to one picomolar concentrations. The system was tested for nonspecific binding interactions with bovine serum albumin and was found to display virtually no adverse results. The extremely sensitive and selective response of the Ag nanoparticle sensor indicates an exciting use for biological and chemical sensing.

Original language	English (US)
Pages (from-to)	133-138
Number of pages	6
Journal	Materials Research Society Symposium - Proceedings
Volume	723
DOIs	https://doi.org/10.1557/proc-723-o3.1
State	Published - 2002
Event	Moleculary Imprinted Materials - Sensors and Other Devices - San Francisco, CA, United States Duration: Apr 2 2002 → Apr 5 2002

ASJC Scopus subject areas

General Materials Science
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

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10.1557/proc-723-o3.1

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abstract = "Nanosphere lithography (NSL) derived triangular Ag nanoparticles were used to create an extremely sensitive and specific optical biological and chemical nanosensor. Using simple UV-vis spectroscopy, biotinylated surface-confined Ag nanoparticles were used to detect streptavidin down to one picomolar concentrations. The system was tested for nonspecific binding interactions with bovine serum albumin and was found to display virtually no adverse results. The extremely sensitive and selective response of the Ag nanoparticle sensor indicates an exciting use for biological and chemical sensing.",

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AU - Van Duyne, Richard P.

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AB - Nanosphere lithography (NSL) derived triangular Ag nanoparticles were used to create an extremely sensitive and specific optical biological and chemical nanosensor. Using simple UV-vis spectroscopy, biotinylated surface-confined Ag nanoparticles were used to detect streptavidin down to one picomolar concentrations. The system was tested for nonspecific binding interactions with bovine serum albumin and was found to display virtually no adverse results. The extremely sensitive and selective response of the Ag nanoparticle sensor indicates an exciting use for biological and chemical sensing.

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T2 - Moleculary Imprinted Materials - Sensors and Other Devices

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A highly sensitive and selective surface-enhanced nanobiosensor

Abstract

ASJC Scopus subject areas

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