A highly sensitive and selective surface-enhanced nanobiosensor

Amanda J. Haes*, Richard P. Van Duyne

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review

18 Scopus citations


Nanosphere lithography (NSL) derived triangular Ag nanoparticles were used to create an extremely sensitive and specific optical biological and chemical nanosensor. Using simple UV-vis spectroscopy, biotinylated surface-confined Ag nanoparticles were used to detect streptavidin down to one picomolar concentrations. The system was tested for nonspecific binding interactions with bovine serum albumin and was found to display virtually no adverse results. The extremely sensitive and selective response of the Ag nanoparticle sensor indicates an exciting use for biological and chemical sensing.

Original languageEnglish (US)
Pages (from-to)133-138
Number of pages6
JournalMaterials Research Society Symposium - Proceedings
StatePublished - 2002
EventMoleculary Imprinted Materials - Sensors and Other Devices - San Francisco, CA, United States
Duration: Apr 2 2002Apr 5 2002

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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