A horseradish peroxidase method for the identification of the efferents of acetyl cholinesterase containing neurons

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Abstract

As a result of this method that enables the simultaneous visualization of AChE and HRP in the same tissue section, the efferent projections of AChE rich perikarya may be determined without ambiguity following intracerebral injections of HRP. In these experiments, this method has enabled a preliminary analysis of efferents from the basal forebrain to neocortex, to the hippocampus and to the olfactory bulb, in terms of both topographical distribution and histochemical specificity. Although the ability to investigate a histochemically distinct group of neurons is inherently of considerable interest, the implication of these AChE rich cells in central cholinergic transmission may introduce additional significance to their connections.

Original languageEnglish (US)
Pages (from-to)1281-1285
Number of pages5
JournalJournal of Histochemistry and Cytochemistry
Volume24
Issue number12
DOIs
StatePublished - 1976

ASJC Scopus subject areas

  • Anatomy
  • Histology

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