A human memory circuit derived from brain lesions causing amnesia

Michael A. Ferguson, Chun Lim, Danielle Cooke, R. Ryan Darby, Ona Wu, Natalia S. Rost, Maurizio Corbetta, Jordan Henry Grafman, Michael D. Fox

Research output: Contribution to journalArticle

Abstract

Human memory is thought to depend on a circuit of connected brain regions, but this hypothesis has not been directly tested. We derive a human memory circuit using 53 case reports of strokes causing amnesia and a map of the human connectome (n = 1000). This circuit is reproducible across discovery (n = 27) and replication (n = 26) cohorts and specific to lesions causing amnesia. Its hub is at the junction of the presubiculum and retrosplenial cortex. Connectivity with this single location defines a human brain circuit that incorporates > 95% of lesions causing amnesia. Lesion intersection with this circuit predicts memory scores in two independent datasets (N1 = 97, N2 = 176). This network aligns with neuroimaging correlates of episodic memory, abnormalities in Alzheimer's disease, and brain stimulation sites reported to enhance memory in humans.

Original languageEnglish (US)
Number of pages1
JournalNature communications
Volume10
Issue number1
DOIs
StatePublished - Aug 2 2019

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Amnesia
lesions
brain
Brain
Data storage equipment
Networks (circuits)
Connectome
Parahippocampal Gyrus
Episodic Memory
Neuroimaging
hubs
cortexes
abnormalities
Alzheimer Disease
strokes
stimulation
Stroke
intersections

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Ferguson, M. A., Lim, C., Cooke, D., Darby, R. R., Wu, O., Rost, N. S., ... Fox, M. D. (2019). A human memory circuit derived from brain lesions causing amnesia. Nature communications, 10(1). https://doi.org/10.1038/s41467-019-11353-z
Ferguson, Michael A. ; Lim, Chun ; Cooke, Danielle ; Darby, R. Ryan ; Wu, Ona ; Rost, Natalia S. ; Corbetta, Maurizio ; Grafman, Jordan Henry ; Fox, Michael D. / A human memory circuit derived from brain lesions causing amnesia. In: Nature communications. 2019 ; Vol. 10, No. 1.
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Ferguson, MA, Lim, C, Cooke, D, Darby, RR, Wu, O, Rost, NS, Corbetta, M, Grafman, JH & Fox, MD 2019, 'A human memory circuit derived from brain lesions causing amnesia', Nature communications, vol. 10, no. 1. https://doi.org/10.1038/s41467-019-11353-z

A human memory circuit derived from brain lesions causing amnesia. / Ferguson, Michael A.; Lim, Chun; Cooke, Danielle; Darby, R. Ryan; Wu, Ona; Rost, Natalia S.; Corbetta, Maurizio; Grafman, Jordan Henry; Fox, Michael D.

In: Nature communications, Vol. 10, No. 1, 02.08.2019.

Research output: Contribution to journalArticle

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