A human memory circuit derived from brain lesions causing amnesia

Michael A. Ferguson; Chun Lim; Danielle Cooke; R. Ryan Darby; Ona Wu; Natalia S. Rost; Maurizio Corbetta; Jordan Grafman; Michael D. Fox

doi:10.1038/s41467-019-11353-z

A human memory circuit derived from brain lesions causing amnesia

Michael A. Ferguson^*, Chun Lim, Danielle Cooke, R. Ryan Darby, Ona Wu, Natalia S. Rost, Maurizio Corbetta, Jordan Grafman, Michael D. Fox

^*Corresponding author for this work

Physical Medicine and Rehabilitation

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Human memory is thought to depend on a circuit of connected brain regions, but this hypothesis has not been directly tested. We derive a human memory circuit using 53 case reports of strokes causing amnesia and a map of the human connectome (n = 1000). This circuit is reproducible across discovery (n = 27) and replication (n = 26) cohorts and specific to lesions causing amnesia. Its hub is at the junction of the presubiculum and retrosplenial cortex. Connectivity with this single location defines a human brain circuit that incorporates > 95% of lesions causing amnesia. Lesion intersection with this circuit predicts memory scores in two independent datasets (N1 = 97, N2 = 176). This network aligns with neuroimaging correlates of episodic memory, abnormalities in Alzheimer’s disease, and brain stimulation sites reported to enhance memory in humans.

Original language	English (US)
Article number	3497
Journal	Nature communications
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41467-019-11353-z
State	Published - Dec 1 2019

ASJC Scopus subject areas

Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
Physics and Astronomy(all)

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AU - Cooke, Danielle

AU - Darby, R. Ryan

AU - Wu, Ona

AU - Rost, Natalia S.

AU - Corbetta, Maurizio

AU - Grafman, Jordan

AU - Fox, Michael D.

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