A hypothalamic activator of calmodulin-dependent enzymes is thymosin β4 (1-39)

A. A. Galoyan, B. Ya Gurvits, L. A. Shuvalova, Michael T. Davis, John E. Shively, Terry D. Lee*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

A new class of stimulators of basal activity of a number of calmodulin-dependent enzymes have been previously isolated from bovine hypothalamus. One of these stimulators, denoted as C3, has been purified to homogeneity by reverse phase HPLC and tentatively identified as thymosin β4 (1-39) by mass spectrometry and Edman microsequence analysis. The stimulating effect of C3 on rabbit skeletal muscle MLCK basal activity was compared with that of thymosin α1 and thymosin β4 (16-38). Evidence is presented that all the indicated compounds are Ca2+-independent high-affinity MLCK stimulators. The potency of the stimulators in activating the enzyme was: C34>(CaM+Ca2+1.

Original languageEnglish (US)
Pages (from-to)773-777
Number of pages5
JournalNeurochemical Research
Volume17
Issue number8
DOIs
StatePublished - Aug 1992

Keywords

  • Thymosin
  • calcium-calmodulin
  • myosin light chain kinase
  • phosphodiesterase

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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