A JAK2/IDH1-mutant MPN clone unmasked by ivosidenib in an AML patient without antecedent MPN

Wenbin Xiao, Linde A. Miles, Robert L. Bowman, Vidushi Durani, Helen S. Tian, Nicole L. DelGaudio, Tanmay Mishra, Menglei Zhu, Yanming Zhang, Sarah E. Stump, Martin S. Tallman, Ross L. Levine, Sheng F. Cai*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations
Original languageEnglish (US)
Pages (from-to)6034-6038
Number of pages5
JournalBlood Advances
Volume4
Issue number23
DOIs
StatePublished - Dec 8 2020

Funding

This work was supported by a Young Investigator Award from the Conquer Cancer Foundation (S.F.C.), Career Development Program Fellow Awards from the Leukemia & Lymphoma Society (S.F.C. and L.A.M.), a Young Investigator Award from The Truth 365 (S.F.C.), a Momentum Award from the Mark Foundation for Cancer Research (S.F.C.), and an ASH Scholar Award (S.F.C.). This research was also funded in part through a Cancer Center Support grant from the National Institutes of Health National Cancer Institute (P30 CA008748). Conflict-of-interest disclosure: W.X. has received research support from Stemline Therapeutics. S.F.C. has consulted for and holds equity interest in Imago Biosciences. R.L.L. serves on the supervisory board of Qiagen and is a scientific advisor to Loxo, Imago, C4 Therapeutics, and Isoplexis; he receives research support from and has consulted for Celgene and Roche; receives research support from Prelude Therapeutics; has consulted for Novartis and Gilead; and has received honoraria from Lilly and Amgen for invited lectures. L.A.M. has received speaking honoraria from Mission Bio, Inc. M.S.T. receives research funding from Abb-Vie, Cellerant, Orsenix, ADC Therapeutics, Biosight, receives royalties from UpToDate, and serves on the advisory boards of AbbVie, BioLineRx, Daiichi-Sankyo, Orsenix, KAHR, Rigel, Nohla, Delta-Fly Pharma, and Tetraphase. The remaining authors declare no competing financial interests.

ASJC Scopus subject areas

  • Hematology

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