A junctional problem of apical proportions: Epithelial tube-size control by septate junctions in the Drosophila tracheal system

Victoria M. Wu, Greg J. Beitel

Research output: Contribution to journalReview article

82 Scopus citations

Abstract

The size of epithelial tubes is critical for the function of organs such as the lung, kidney and vascular system. However, the molecular mechanisms regulating tube size are largely unknown. Recent work in the Drosophila tracheal system reveals that septate junctions play a previously unsuspected role in tube-size control. Surprisingly, this tube-size function is distinct from the established diffusion barrier function of septate junctions, and involves regulation of cell shape rather than cell number. Possible tube-size functions of septate junctions include patterning of the apical extracellular matrix and regulation of conserved cell polarity genes such as Scribble and Discs Large.

Original languageEnglish (US)
Pages (from-to)493-499
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume16
Issue number5
DOIs
StatePublished - Oct 1 2004

Keywords

  • ATPα
  • Cor
  • Coracle
  • DaPKC
  • Discs Large
  • Dlg
  • ECM
  • EM
  • Gli
  • Gliotactin
  • Lac
  • Lachesin
  • Lethal Giant Larvae
  • Lgl
  • Mega
  • Megatrachea
  • Nrg
  • atypical protein kinase C
  • electron microscopy
  • extracellular matrix
  • α subunit of the NaK ATPase ion transporter

ASJC Scopus subject areas

  • Cell Biology

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