A knowledge-based system for cassette mutagenesis experimental design

J. Zheng*, K. Jiang, D. M. Watterson, T. A. Craig, S. B. Higgins

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


A knowledge-based system for the design and planning of cassette mutagenesis experiments has been developed for scientists working in the field of structural biology and protein engineering. The system applies domain-specific knowledge to manage the menial details and automate most of the decision-making steps involved in the design process. This allows scientists to work at a high abstraction level, and results in significant time savings and increased productivity. The system also includes an automated documentation facility to improve the efficiency and accuracy of record keeping.

Original languageEnglish (US)
Pages (from-to)409-418
Number of pages10
JournalComputers in Biology and Medicine
Issue number6
StatePublished - 1988


  • Expert system
  • Knowledge-based system
  • Mutagenesis
  • Protein engineering
  • Structural biology

ASJC Scopus subject areas

  • Computer Science Applications
  • Health Informatics


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