A large-scale study of the ultrawideband microwave dielectric properties of normal, benign and malignant breast tissues obtained from cancer surgeries

Mariya Lazebnik*, Dijana Popovic, Leah McCartney, Cynthia B. Watkins, Mary J. Lindstrom, Josephine Harter, Sarah Sewall, Travis Ogilvie, Anthony Magliocco, Tara M. Breslin, Walley Temple, Daphne Mew, John H. Booske, Michal Okoniewski, Susan C. Hagness

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

840 Scopus citations

Abstract

The development of microwave breast cancer detection and treatment techniques has been driven by reports of substantial contrast in the dielectric properties of malignant and normal breast tissues. However, definitive knowledge of the dielectric properties of normal and diseased breast tissues at microwave frequencies has been limited by gaps and discrepancies across previously published studies. To address these issues, we conducted a large-scale study to experimentally determine the ultrawideband microwave dielectric properties of a variety of normal, malignant and benign breast tissues, measured from 0.5 to 20 GHz using a precision open-ended coaxial probe. Previously, we reported the dielectric properties of normal breast tissue samples obtained from reduction surgeries. Here, we report the dielectric properties of normal (adipose, glandular and fibroconnective), malignant (invasive and non-invasive ductal and lobular carcinomas) and benign (fibroadenomas and cysts) breast tissue samples obtained from cancer surgeries. We fit a one-pole Cole-Cole model to the complex permittivity data set of each characterized sample. Our analyses show that the contrast in the microwave-frequency dielectric properties between malignant and normal adipose-dominated tissues in the breast is considerable, as large as 10:1, while the contrast in the microwave-frequency dielectric properties between malignant and normal glandular/fibroconnective tissues in the breast is no more than about 10%.

Original languageEnglish (US)
Pages (from-to)6093-6115
Number of pages23
JournalPhysics in Medicine and Biology
Volume52
Issue number20
DOIs
StatePublished - Oct 21 2007

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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